Continuous melt granulation to develop high drug loaded sustained release tablet of Metformin HCl [PDF]
Asian Journal of Pharmaceutical Sciences, 2017 The present work explores the application of melt granulation technology to develop a high drug loaded sustained release matrix tablet of Metformin HCl using hydroxypropylcellulose (HPC) as a hydrophilic binder and stearic acid as an extrusion aid for ...
Pradnya Vaingankar, Purnima Amin
doaj +2 more sources
The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation—From the Lab Scale to the Pilot Scale [PDF]
PharmaceuticsSolid pharmaceutical formulations with class II active pharmaceutical ingredients (APIs) face dissolution challenges due to limited solubility, affecting in vivo behavior.
Béla Kovács +7 more
doaj +2 more sources
Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends [PDF]
PharmaceuticsBackground/Objectives: This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability.
Rasha M. Elkanayati +6 more
doaj +2 more sources
Formulation of ketotifen fumarate fast-melt granulation sublingual tablet. [PDF]
AAPS PharmSciTech, 2010 The purpose of this study was to prepare sublingual tablets, containing the antiasthmatic drug ketotifen fumarate which suffers an extensive first-pass effect, using the fast-melt granulation technique. The powder mixtures containing the drug were agglomerated using a blend of polyethylene glycol 400 and 6000 as meltable hydrophilic binders.
Tayel SA, Soliman II, Louis D.
europepmc +4 more sources
MELT GRANULATION IN HIGH SHEAR MIXER
Vitae, 2009 Melt granulation in a high-shear mixer is an alternative technique that converts fine powders into granules. The powder agglomeration is promoted by the addition of a low melting point binder, which is solid at room temperature and melts at relatively ...
Lourdes OCHOA D. +4 more
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of present study was to prepare and characterize Bilayer tablet formulation containing Metformin HCl in extended release matrix form and Pioglitazone HCl in immediate release form for the treatment of diabetes mellitus.
Dhruvita Patel +2 more
doaj +2 more sources
Enhancing Patient-Centric Drug Development: Coupling Hot Melt Extrusion with Fused Deposition Modeling and Pressure-Assisted Microsyringe Additive Manufacturing Platforms with Quality by Design [PDF]
PharmaceuticsIn recent years, with the increasing patient population, the need for complex and patient-centric medications has increased enormously. Traditional manufacturing techniques such as direct blending, high shear granulation, and dry granulation can be used ...
Dinesh Nyavanandi +5 more
doaj +2 more sources
British Journal of Pharmacy, 2022 The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative ...
Valentyn Mohylyuk +4 more
doaj +1 more source
The Impacts of Method Selectivity and Binders on the Properties of Carbamazepine Granules and Their Applications: A Case Study [PDF]
Pharmaceutical Sciences, 2022 Background: Carbamazepine (CBZ) is a BCS II class drug, having many challenges in solubility, flowability, and compactibility. The study focused on the improvement of solubility, flow behavior, and drug release of carbamazepine.
Rahul Tatyarao Shete +2 more
doaj +1 more source
Physico-chemical properties lime-ammonium nitrate based on chalk, nitrate and ammonium sulphate [PDF]
E3S Web of Conferences, 2021 For the granulation of nitrate-sulfate-carbonate melt, the prilling method is applied using a granulation tower. The composition and properties of new types of fertilizers were studied.
Rasulov Oybek +4 more
doaj +1 more source