Results 1 to 10 of about 38,408 (255)
Ibrain, 2023 Memantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989.
Bin-Can Tang, Ya-Ting Wang
exaly +2 more sources
MeMAGEN: A Phase IIa/IIb open‐label trial of memantine testing safety and tolerability in sickle cell patients [PDF]
HemaSphereAdministration of memantine, an antagonist of the N‐methyl‐ d‐aspartate receptor, prevents Ca2+ overload and dehydration of red blood cells (RBCs) in patients with sickle cell disease (SCD).
Ariel Koren +7 more
doaj +2 more sources
The NMDA antagonist memantine affects training induced motor cortex plasticity – a study using transcranial magnetic stimulation [ISRCTN65784760] [PDF]
BMC Neuroscience, 2005 Background Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping.
Schwenkreis Peter +4 more
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Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation [PDF]
Frontiers in Oncology, 2023 IntroductionCranial irradiation (IR) negatively regulates hippocampal neurogenesis and causes cognitive dysfunctions in cancer survivors, especially in pediatric patients. IR decreases proliferation of neural stem/progenitor cells (NSPC) and consequently
Georgios Alkis Zisiadis +6 more
doaj +2 more sources
Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study [PDF]
Annals of Clinical and Translational NeurologyObjective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited.
Peiyu Wang +7 more
doaj +2 more sources
International Journal of Electrochemical Science, 2009 Memantine (MEM) is one of the first novel class medications for treatment of Alzheimer's disease. In this study a potentiometric liquid membrane sensor is used for simple and fast determination of Memantine in pharmaceutical formulation and urine ...
Mohammad R Ganjali, Parviz Norouzi
exaly +3 more sources
Update on the use of memantine in Alzheimer’s disease
Neuropsychiatric Disease and Treatment, 2009 Robert J van MarumGeriatric Department, University Medical Center Utrecht, Utrecht, The NetherlandsAbstract: Memantine is a low to moderate affinity N-methyl-D-aspartate receptor (NMDAR) antagonist.
Robert J van Marum
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Journal of Prescribing Practice, 2021 In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of tweets. This month she is talking about #memantine
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Pharmaceuticals, 2022 Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity.
Radoslav Chayrov +7 more
doaj +1 more source
The Highs and Lows of Memantine—An Autophagy and Mitophagy Inducing Agent That Protects Mitochondria
Cells, 2023 Memantine is an FDA-approved, non-competitive NMDA-receptor antagonist that has been shown to have mitochondrial protective effects, improve cell viability and enhance clearance of Aβ42 peptide.
Sholto de Wet +7 more
doaj +1 more source