Basic Information About Memantine and Its Treatment of Alzheimer's Disease and Other Clinical Applications [PDF]
Ibrain, 2023 Memantine is a noncompetitive moderate‐affinity strong voltage‐dependent N‐methyl‐D‐aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989.
Ya-Ting Wang, Bin-Can Tang
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An Experimental Study on the Protective Effect of Memantine in Noise-Induced Hearing Loss. [PDF]
World J Otorhinolaryngol Head Neck SurgABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Arda B +6 more
europepmc +2 more sources
International Journal of Electrochemical Science, 2009 Memantine (MEM) is one of the first novel class medications for treatment of Alzheimer's disease. In this study a potentiometric liquid membrane sensor is used for simple and fast determination of Memantine in pharmaceutical formulation and urine ...
P Norouzi, S Riahi, M R Ganjali
exaly +3 more sources
Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments [PDF]
Pharmacology Research & PerspectivesCognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (
Motohiro Okada +3 more
doaj +2 more sources
Memantine, acetylcholinesterase inhibitors, and quality‐of‐care outcomes among patients with cognitive impairment: an emulated trial design [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION We evaluated the effect of acetylcholinesterase inhibitors (AChEIs) and memantine on non‐cognitive outcomes by implementing emulated trials in electronic health records.
Erin L. Ferguson +8 more
doaj +2 more sources
Pharmaceuticals, 2022 Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity.
Radoslav Chayrov +7 more
doaj +1 more source
The Highs and Lows of Memantine—An Autophagy and Mitophagy Inducing Agent That Protects Mitochondria
Cells, 2023 Memantine is an FDA-approved, non-competitive NMDA-receptor antagonist that has been shown to have mitochondrial protective effects, improve cell viability and enhance clearance of Aβ42 peptide.
Sholto de Wet +7 more
doaj +1 more source
BMC Neurology, 2022 Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition.
Shoji Kawashima +2 more
doaj +1 more source
The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023 Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani +5 more
doaj
The cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer.
Sima Seifabadi +5 more
doaj +1 more source