Results 11 to 20 of about 38,408 (255)
Cochrane Database of Systematic Reviews, 2019 Memantine is a moderate affinity uncompetitive antagonist of glutamate NMDA receptors. It is licensed for use in moderate and severe Alzheimer's disease (AD); in the USA, it is also widely used off-label for mild AD.To determine efficacy and safety of memantine for people with dementia. To assess whether memantine adds benefit for people already taking
Rupert, McShane +8 more
openaire +2 more sources
BMC Neurology, 2022 Background Mild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition.
Shoji Kawashima +2 more
doaj +1 more source
Drugs & Aging, 2003 Memantine, an uncompetitive antagonist with moderate affinity for NMDA receptors, demonstrates voltage-dependency and relatively fast on/off receptor kinetics. Memantine 20 mg/day significantly slowed the rate of deterioration in outpatients with moderate to severe Alzheimer's disease in a 28-week US randomised, double-blind, placebo-controlled ...
Blair, Jarvis, David P, Figgitt
+6 more sources
The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2023 Background and Objectives: Studies have indicated that the chronic use of morphine can result in physical and psychological dependence. Morphine dependence is associated with several cellular and molecular alterations in the mesocorticolimbic system, and
Sahar Khalili Samani +5 more
doaj
The cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer.
Sima Seifabadi +5 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Obsessive–compulsive disorder (OCD) is a psychiatric disorder with alterations of cortico‐striato‐thalamo‐cortical loops and impaired performance monitoring. Electrophysiological markers such as conflict‐related medial frontal theta (MFT) and error‐related negativity (ERN) may be altered by clinically effective deep brain ...
Elena Sildatke +9 more
wiley +1 more source
Effect of memantine, an anti-Alzheimer’s drug, on rodent microglial cells in vitro
Scientific Reports, 2021 The pathophysiology of Alzheimer’s disease (AD) is related to neuroinflammatory responses mediated by microglia. Memantine, an antagonist of N-methyl-d-aspartate (NMDA) receptors used as an anti-Alzheimer’s drug, protects from neuronal death accompanied ...
Toru Murakawa-Hirachi +4 more
doaj +1 more source
Nootropics use in the workplace. Psychiatric and ethical aftermath towards the new frontier of bioengineering [PDF]
, 2020 OBJECTIVE: The authors have sought to expound upon and shed a light on the rise of nootropics, which have gradually taken on a more and more relevant role in workplaces and academic settings.
Bersani, G +5 more
core +1 more source
Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
Pharmaceutics, 2018 A sensitive and simple chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to evaluate memantine in rat plasma. Memantine and propranolol (internal standard) in rat plasma was extracted using a methanol precipitation method.
Young A. Choi +2 more
doaj +1 more source
Memantine for prevention of migraine: a retrospective study of 60 cases. [PDF]
, 2007 The objective was to retrospectively characterise the efficacy of memantine as preventive therapy in a series of patients with frequent migraine. Patients in a university headache clinic completed a survey regarding their experience with memantine, and ...
Brennan, Kevin C +3 more
core +1 more source