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Structural Biology of the Membrane Attack Complex
Sub-cellular biochemistry, 2014The complement system is an intricate network of serum proteins that mediates humoral innate immunity through an amplification cascade that ultimately leads to recruitment of inflammatory cells or opsonisation or killing of pathogens. One effector arm of this network is the terminal pathway of complement, which leads to the formation of the membrane ...
Sonnen, Andreas F.-P., Henneke, Philipp
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Springer Seminars in Immunopathology, 1984
The “killer molecule” of complement is the membrane attack complex (MAC). It constitutes a supramolecular organization that is composed of approximately 20 protein molecules and has a molecular weight of about 1.7 million. The complex has five precursors, C5, C6, C7, C8, and C9, which are hydrophilic glycoproteins with molecular weights ranging from 70
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The “killer molecule” of complement is the membrane attack complex (MAC). It constitutes a supramolecular organization that is composed of approximately 20 protein molecules and has a molecular weight of about 1.7 million. The complex has five precursors, C5, C6, C7, C8, and C9, which are hydrophilic glycoproteins with molecular weights ranging from 70
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The membrane attack complex ofXeopus laevis complement
Experientia, 1987Rabbit erythrocyte membranes lyzed by Xenopus laevis serum exhibited a typical ultrastructural complement lesion with an inner diameter of 80 +/- 9 A. The protein pattern associated with lyzed membrane is compared to a similar human preparation.
C, Canicatti, F, Veuthey
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Membrane permeability to macromolecules mediated by the membrane attack complex
Biochemistry, 1989A simple and well-defined system of purified phospholipids and human complement proteins was used to study membrane permeability to macromolecules mediated by the membrane attack complex (MAC) of complement. Large unilamellar vesicles (LUVs) of phosphatidylcholine (PC) or phosphatidylserine (PS) containing trapped macromolecules [bovine pancreatic ...
J A, Malinski, G L, Nelsestuen
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Membrane signaling by complement C5b-9, the membrane attack complex
Immunologic Research, 1993The terminal complement complexes C5b-7, C5b-8 and C5b-9 are able to generate nonlethal cell signals. One universal consequence of a cell being targeted by C5b-8 or C5b-9 is an influx of Ca2+. In addition, other second messengers, including cAMP, inositol phosphate intermediates and arachidonate metabolites, are generated by the terminal complement ...
A, Nicholson-Weller, J A, Halperin
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Complement Membrane Attack Complexes in Pathologic Disc Tissues
Spine, 2003Complement membrane attack complexes were located in lumbar spine disc tissues by immunohistochemistry. Their occurrence was compared in control discs obtained from organ donors (CD), discs showing a normal macroscopic anatomy, samples of intervertebral disc herniations (DH), and intervertebral discs found to be degenerated by discography, but not ...
Mats, Grönblad +5 more
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Seminars in Arthritis & Rheumatism, 2018
OBJECTIVE To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment. METHODS Immunohistochemistry was performed using unconjugated, murine anti-human complement
Shudan Wang +4 more
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OBJECTIVE To study membrane attack complex in lupus nephritis as a potential biomarker for disease intensity and prognostic indicator for response to treatment. METHODS Immunohistochemistry was performed using unconjugated, murine anti-human complement
Shudan Wang +4 more
semanticscholar +1 more source
The Membrane Attack Complex of Complement
Annual Review of Immunology, 1986Cell-killing mechanisms are essential components of host defense against infectious agents, parasites, and malignant cells. We distinguish humoral and cellular killing mechanisms. Complement utilizes specific proteins to assemble its killer molecule. Macrophages generate active oxygen radicals that injure target membranes. Lymphocytes, like complement,
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Membrane Attack Complex Deposits in Cutaneous Lesions of Dermatomyositis
Archives of Dermatology, 1995The presence of membrane attack complex of complement (MAC) deposits in the intramuscular vasculature of biopsy specimens taken from patients with dermatomyositis (DM) has been implicated in the pathogenesis of this myopathy. The purpose of this study was to investigate the presence of MAC deposition in the skin lesions of patients with DM.
J M, Mascaró +6 more
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Microvascular Deposition of Complement Membrane Attack Complex in Dermatomyositis
New England Journal of Medicine, 1986We examined the role of the complement system in the pathogenesis of dermatomyositis. Using an antibody against the neoantigens of the terminal C5b-9 membrane attack complex, we performed immunocytochemical studies that localized this complex to the intramuscular microvasculature (arterioles and capillaries) of muscle biopsy specimens from 10 of 12 ...
J T, Kissel, J R, Mendell, K W, Rammohan
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