Results 191 to 200 of about 116,413 (235)
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Membrane signaling by complement C5b-9, the membrane attack complex
Immunologic Research, 1993The terminal complement complexes C5b-7, C5b-8 and C5b-9 are able to generate nonlethal cell signals. One universal consequence of a cell being targeted by C5b-8 or C5b-9 is an influx of Ca2+. In addition, other second messengers, including cAMP, inositol phosphate intermediates and arachidonate metabolites, are generated by the terminal complement ...
A, Nicholson-Weller, J A, Halperin
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Formation and regulation of the membrane attack complex
1997Abstract Complement was originally discovered more than a century ago because of its haemolytic and bacteriolytic activities, both consequences of the poreforming capacity of the membrane attack complex (MAC). Following cleavage of CS by the convertase of either activation pathway, the five terminal components of complement (C5b through ...
B Paul Morgan, Carmen W Van Den Berg
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The fluid-phase assembly of the membrane attack complex of complement
Biochemistry, 1986The dynamics and protein stoichiometry of the fluid-phase assembly of the membrane attack complex of complement were characterized by using light-scattering intensity measurements. The assembly proceeded in an ordered manner with generation of stable and highly reproducible intermediates.
R E, Silversmith, G L, Nelsestuen
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Membrane Attack Complex Deposits in Cutaneous Lesions of Dermatomyositis
Archives of Dermatology, 1995The presence of membrane attack complex of complement (MAC) deposits in the intramuscular vasculature of biopsy specimens taken from patients with dermatomyositis (DM) has been implicated in the pathogenesis of this myopathy. The purpose of this study was to investigate the presence of MAC deposition in the skin lesions of patients with DM.
J M, Mascaró +6 more
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Complement Membrane Attack Complexes in Pathologic Disc Tissues
Spine, 2003Complement membrane attack complexes were located in lumbar spine disc tissues by immunohistochemistry. Their occurrence was compared in control discs obtained from organ donors (CD), discs showing a normal macroscopic anatomy, samples of intervertebral disc herniations (DH), and intervertebral discs found to be degenerated by discography, but not ...
Mats, Grönblad +5 more
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Microvascular Deposition of Complement Membrane Attack Complex in Dermatomyositis
New England Journal of Medicine, 1986We examined the role of the complement system in the pathogenesis of dermatomyositis. Using an antibody against the neoantigens of the terminal C5b-9 membrane attack complex, we performed immunocytochemical studies that localized this complex to the intramuscular microvasculature (arterioles and capillaries) of muscle biopsy specimens from 10 of 12 ...
J T, Kissel, J R, Mendell, K W, Rammohan
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Is the membrane attack complex of complement an enzyme?
Molecular and Cellular Biochemistry, 1984Recent studies on the functional activities of the membrane attack complex of complement, C5b-9, are reviewed. A new speculative hypothesis has been advanced to account for the ability of complement to mediate lysis of various targets. This hypothesis has three major elements: 1) that the membrane attack complex is an enzyme; 2) that the substrate for ...
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The cobra complement system: II. The membrane attack complex
Developmental & Comparative Immunology, 1985Rabbit erythrocytes are lysed by cobra plasma. The membranes of the lysed rabbit erythrocytes exhibited typical ultrastructural complement lesions with an inner diameter of 72 A. Structures similar to human C5b-8 complexes were also visualized. The proteins found in membranes lysed by cobra plasma resembled closely the proteins of the human membrane ...
C W, Vogel, H J, Müller-Eberhard
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Programmable membrane attack complex
Biophysical Journal, 2022Wachara Chanakul +2 more
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Cellular responses to the membrane attack complex
1993Complement was first identified over a century ago as a result of the observation that fresh serum caused lysis of bacteria and erythrocytes -activities we now recognize as being mediated by the membrane attack complex (MAC). It is not surprising that, until recently, the MAC was considered by the majority of immunologists, and even by ...
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