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Mechanisms of Tissue Damage by the Membrane Attack Complex of Complement
Complement and Inflammation, 2017This article explores the role of the cytolytic membrane attack complex of complement in the pathogenesis of inflammatory diseases. Evidence of nucleated cell resistance to lysis by the membrane attack complex and the stimulation of secretion of pro-inflammatory factors in the absence of cell death in a variety of cell types in vitro are documented ...
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The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex
Biochemistry, 2014The complement terminal pathway clears pathogens by generating cytotoxic membrane attack complex (MAC) pores on target cells. For more than 40 years, biochemical and cellular assays have been used to characterize the lytic nature of the MAC and to define its protein composition.
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Effects of the Membrane Attack Complex of Complement on Nucleated Cells
1992In the last quarter of the nineteenth century several workers described the heatlabile lytic action of serum on bacteria and erythrocytes, and it was these observations which led to the discovery of the complement system (Nuttal 1888; Bordet 1898; Ehrlich and Morgenroth 1899).
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Transience of membrane channels induced by perforin and by the membrane attack complex
Biochemical Society Transactions, 1990J, Jones, B P, Morgan
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Membrane attack complex of complement: a structural analysis of its assembly.
Journal of Experimental Medicine, 1980E R Podack, G Biesecker, A F Esser
exaly
Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis.
Journal of Experimental Medicine, 1981D Köffler, G Biesecker
exaly
THE MEMBRANE ATTACK MECHANISM OF COMPLEMENT : VERIFICATION OF A STABLE C5-9 COMPLEX IN FREE SOLUTION
Journal of Experimental Medicine, 1973William P Kolb, W P Kolb
exaly