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The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex
Biochemistry, 2014The complement terminal pathway clears pathogens by generating cytotoxic membrane attack complex (MAC) pores on target cells. For more than 40 years, biochemical and cellular assays have been used to characterize the lytic nature of the MAC and to define its protein composition.
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Cellular responses to the membrane attack complex
1993Complement was first identified over a century ago as a result of the observation that fresh serum caused lysis of bacteria and erythrocytes -activities we now recognize as being mediated by the membrane attack complex (MAC). It is not surprising that, until recently, the MAC was considered by the majority of immunologists, and even by ...
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Effects of the Membrane Attack Complex of Complement on Nucleated Cells
1992In the last quarter of the nineteenth century several workers described the heatlabile lytic action of serum on bacteria and erythrocytes, and it was these observations which led to the discovery of the complement system (Nuttal 1888; Bordet 1898; Ehrlich and Morgenroth 1899).
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Transience of membrane channels induced by perforin and by the membrane attack complex
Biochemical Society Transactions, 1990J, Jones, B P, Morgan
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Membrane attack complex of complement: a structural analysis of its assembly.
Journal of Experimental Medicine, 1980E R Podack, A F Esser, G Biesecker
exaly
Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis.
Journal of Experimental Medicine, 1981G Biesecker, D Köffler
exaly
THE MEMBRANE ATTACK MECHANISM OF COMPLEMENT
Journal of Experimental Medicine, 1973William P Kolb, Muller-Eberhard Hans J
exaly