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Structural Biology of the Membrane Attack Complex
2014The complement system is an intricate network of serum proteins that mediates humoral innate immunity through an amplification cascade that ultimately leads to recruitment of inflammatory cells or opsonisation or killing of pathogens. One effector arm of this network is the terminal pathway of complement, which leads to the formation of the membrane ...
Sonnen, Andreas F.-P., Henneke, Philipp
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Membrane Attack Complex Deposits in Cutaneous Lesions of Dermatomyositis
Archives of Dermatology, 1995The presence of membrane attack complex of complement (MAC) deposits in the intramuscular vasculature of biopsy specimens taken from patients with dermatomyositis (DM) has been implicated in the pathogenesis of this myopathy. The purpose of this study was to investigate the presence of MAC deposition in the skin lesions of patients with DM.
J M, Mascaró +6 more
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The cobra complement system: II. The membrane attack complex
Developmental & Comparative Immunology, 1985Rabbit erythrocytes are lysed by cobra plasma. The membranes of the lysed rabbit erythrocytes exhibited typical ultrastructural complement lesions with an inner diameter of 72 A. Structures similar to human C5b-8 complexes were also visualized. The proteins found in membranes lysed by cobra plasma resembled closely the proteins of the human membrane ...
C W, Vogel, H J, Müller-Eberhard
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Channel fluctuations induced by membrane attack complex C5b-9
Molecular Immunology, 1990The assembly of complement (C) components C5b-9 in membranes results in the formation of transmembrane lesions. The C9 component has been shown to be mainly responsible for formation of the ultrastructurally visible tubules associated with C5b-9 complexes.
J D, Young, T M, Young
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Membrane Attack Complex of Complement in Dermatitis Herpetiformis
Archives of Dermatology, 1985• The assembly of membrane attack complex (MAC) of complement implies activation of complement to the attachment of C9 and the presence of MAC on tissue suggests a possible pathogenic role for complement in disease since MAC is able to damage membranes. We examined normal skin of five patients with dermatitis herpetiformis for the presence of MAC using
M V, Dahl +3 more
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Programmable membrane attack complex
Biophysical Journal, 2022Wachara Chanakul +2 more
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["Membrane attack complex" formation in hemodialysis treatment].
Wiener klinische Wochenschrift, 1990The behaviour of plasma concentrations of the membrane attack complex (MAC) during haemodialysis was studied in 23 patients. An increase in the levels up to 250% of the initial value was noted when Hemophan or Cuprophan membranes were used. Patients dialyzed, with Polysulfon membranes showed only a slight increase in MAC levels.
A C, Hauser +4 more
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Formation and regulation of the membrane attack complex
1997Abstract Complement was originally discovered more than a century ago because of its haemolytic and bacteriolytic activities, both consequences of the poreforming capacity of the membrane attack complex (MAC). Following cleavage of CS by the convertase of either activation pathway, the five terminal components of complement (C5b through ...
B Paul Morgan, Carmen W Van Den Berg
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Cellular responses to the membrane attack complex
1993Complement was first identified over a century ago as a result of the observation that fresh serum caused lysis of bacteria and erythrocytes -activities we now recognize as being mediated by the membrane attack complex (MAC). It is not surprising that, until recently, the MAC was considered by the majority of immunologists, and even by ...
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Membrane attack complex deposition in experimental glomerular injury.
The American journal of pathology, 1985The complement (C) system is an important mediator of glomerular injury both through its attraction of inflammatory cells and by a cell-independent effect on glomerular capillary wall permeability. We have postulated that the latter effect may be mediated by the terminal components of the C system, the membrane attack complex (MAC). We examined several
D T, Perkinson +4 more
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