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ER-Golgi membrane contact sites
Biochemical Society Transactions, 2020Membrane contact sites (MCSs) are sites where the membranes of two different organelles come into close apposition (10–30 nm). Different classes of proteins populate MCSs including factors that act as tethers between the two membranes, proteins that use the MCSs for their function (mainly lipid or ion exchange), and regulatory proteins and enzymes that
Venditti, Rossella +2 more
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Regulation and physiology of membrane contact sites
Current Opinion in Cell Biology, 2021Membrane contact sites (MCSs) in addition to impacting the functions of membrane-limited organelles also have a role in the spatial and functional organization of cells, tissues and whole organisms. MCSs have been identified between all organelles and the identification of their molecular composition has progressed significantly in recent years ...
Venditti R., Wilson C., De Matteis M. A.
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Phosphoinositides in membrane contact sites
Biochemical Society Transactions, 2016Cellular membranes communicate extensively via contact sites that form between two membranes. Such sites allow exchange of specific ions, lipids or proteins between two compartments without content mixing, thereby preserving organellar architecture during the transfer process. Even though the molecular compositions of membrane contact sites are diverse,
Camilla, Raiborg +3 more
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StARTing to understand membrane contact sites
Trends in Cell Biology, 2015Lipid transport proteins localized to membrane contact sites mediate the distribution of lipids between organelles. Recently identified StART-like sterol transporting proteins in yeast can explain sterol delivery within the cell. The multiple localizations of these proteins could provide alternative routes for sterol delivery and mediate inter ...
Ayelén, González Montoro +1 more
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Endoplasmic reticulum–Golgi complex membrane contact sites
Current Opinion in Cell Biology, 2015Although they were identified as long ago as the 1960s, there are still many unknowns regarding the functions and composition of membrane contact sites between the endoplasmic reticulum (ER) and the trans-Golgi (TG). While it seems to be fairly well established that they facilitate lipid exchange between the two organelles, much less is known about how
DE MATTEIS, Maria Antonietta +1 more
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2015
The rough endoplasmic reticulum (RER) in mammalian cells forms an intricate network. It has long been noticed that it can be in close apposition to other organelles such as mitochondria. Electron microscopic analysis and biochemical analysis have provided insight in the functional importance and molecular composition of such organelle contact sites.
Margit Pavelka, Jürgen Roth
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The rough endoplasmic reticulum (RER) in mammalian cells forms an intricate network. It has long been noticed that it can be in close apposition to other organelles such as mitochondria. Electron microscopic analysis and biochemical analysis have provided insight in the functional importance and molecular composition of such organelle contact sites.
Margit Pavelka, Jürgen Roth
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Endoplasmic reticulum: Membrane contact sites
Cell and Tissue Biology, 2013The review of modern data about a functional purpose of membrane contact sites (MCSs) of endoplasmic reticulum is presented. Traffic problems of lipids and calcium in MCSs are discussed. The sufficient condition for giving MCSs of certain functional is not received till now; the problem of the "anchors" providing contact of two membranes, definitively ...
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Intrinsically disordered protein regions at membrane contact sites
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021Membrane contact sites (MCS) are regions of close apposition between membrane-bound organelles. Proteins that occupy MCS display various domain organisation. Among them, lipid transfer proteins (LTPs) frequently contain both structured domains as well as regions of intrinsic disorder.
Denisa, Jamecna, Bruno, Antonny
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Directing lipid transport at membrane contact sites
Nature Cell Biology, 2016Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.
Michael, Krauβ, Volker, Haucke
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The mitochondria–plasma membrane contact site
Current Opinion in Cell Biology, 2015Mitochondria are dynamic organelles that are highly motile and frequently fuse and divide. It has recently become clear that their complex behavior is governed to a large extent by interactions with other cellular structures. This review will focus on a mitochondria-plasma membrane tethering complex that was recently discovered and molecularly analyzed
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