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Temporal dynamics of membrane contact sites
Nature Cell BiologyCell behaviour changes temporally in response to environmental and metabolic cues. This also applies to membrane contact sites (MCSs), where organelles come into close proximity to perform specific functions, such as lipid transfer or calcium signalling. Here, we discuss how MCSs change over time and whether MCSs exhibit circadian rhythmicity.
Knedlik T., Giacomello M.
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Cholesterol transfer at endosomal-organelle membrane contact sites
Current Opinion in Lipidology, 2018Purpose of review Cholesterol is delivered to the limiting membrane of late endosomes by Niemann–Pick Type C1 and C2 proteins. This review summarizes recent evidence that cholesterol transfer from endosomes to the endoplasmic reticulum and other organelles is mediated by lipid-binding proteins that localize to membrane contact ...
Neale D, Ridgway, Kexin, Zhao
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Membrane contact sites promote lipid exchange
Science, 2015The endoplasmic reticulum proteins ORP5 and ORP8 mediate PI4P-phosphatidylserine exchange at contact sites with the plasma membrane.
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Ca2+ Fluxes across Membrane Contact Sites
Cold Spring Harbor Perspectives in Biology: The calcium ion (Ca2+) is a pivotal second messenger orchestrating diverse cellular functions, including metabolism, signaling, and apoptosis. Membrane contact sites (MCSs) are critical hubs for Ca2+ exchange, enabling rapid and localized signaling across cell compartments.
Barazzuol, Lucia +2 more
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Contact sites between mitochondrial membranes: comments.
Cytobios, 1992Extensive contact sites between the two mitochondrial membranes are visualized particularly when tissues are prepared by freeze-substitution methods for electron microscopy. Such contacts rapidly diminish if animals are asphyxiated even for a relatively short period of 8 min. Thus contacts between the mitochondrial membranes are likely to be labile.
S K, Malhotra, J P, Tewari
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Phosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology, 2022York Posor, Wonyul Jang, Volker Haucke
exaly
The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites
International Journal of Molecular Sciences, 2021Samantha K Dziurdzik, Elizabeth Conibear
exaly
Membrane contact sites in endothelial cells
Atherosclerosis, 2016A. Kivelä, V. Olkkonen
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