Results 91 to 100 of about 1,549,978 (301)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Emerging breakthroughs in membrane filtration techniques and their application in agricultural wastewater treatment: Reusability aspects

Sustainable Chemistry for the Environment
Freshwater resources are becoming limited and are rapidly getting polluted due to industrialization and urbanization. Water pollution is a pervasive global challenge both in terms of scarcity and quality.
R. Kamalesh, S. Karishma, A. Saravanan, P.R. Yaashikaa   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chemical cleaning of potable water membranes: A review [PDF]

, 2010
The literature on chemical cleaning of polymeric hollow fibre ultrafiltration and microfiltration membranes used in the filtration of water for municipal water supply is reviewed. The review considers the chemical cleaning mechanism, and the perceived
Porcelli, Nicandro, Judd, Simon J.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of the ability to control ammonium, nitrate and nitrite in water using membrane filtration technology

Tạp chí Kiểm nghiệm và An toàn thực phẩm
Domestic water sources in rural areas could be polluted by ammonium, nitrite and nitrate. These compounds affected to human health. Therefore, development of membrane filtration system to control the above pollution parameters is essential. In this study,
Dinh Tung Duong, Pham Thu Thao, Do Khac Uan   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PREPARATION MICRO-FILTRATION CERAMIC MEMBRANE FROM NATURAL ZEOLITE FOR PROCION RED MX8B AND METHYLENE BLUE FILTRATION

Alchemy, 2015
The study of ceramic membrane fabrication from natural zeolite and its utilization for filtration of procion red MX8B and methylene blue has been investigated.
Dyah Choiriyah, Esfi Riandini, Arinta Wulandari, Oktaviana Dewi Indah, P Alifia, Harista Rachma, Edi Pramono   +6 more
doaj   +1 more source

Development of novel membranes based on electro-spun nanofibers and their application in liquid filtration, membrane distillation and membrane adsorption

, 2010
Electro spinning is known as a simple and versatile method to produce nonwoven membranes made out of nanofibers. A wide range of polymers and blends can be used to yield nanofibers.
Gopal, R., Khulbe, K. C., Matsuura, T., Feng, C., Rana, D., Singh, G.   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source