Results 71 to 80 of about 678,998 (299)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Membrane Lipid Switches: How Membrane Lipid Structure Influences Protein–Lipid Interactions [PDF]

, 2020
Peripheral membrane proteins are required for signal propagation upon ligand-induced receptor activation at the plasma membrane. The translocation of this amphitropic peripheral proteins from or to the plasma membrane enables signal cascade propagation into the cells.
Manuel Torres, Catalina Ana Rosselló, Paula Fernández García, Victoria Llado, Pablo V Escribá   +4 more
openaire   +1 more source

Inverse Association between trans Isomeric and Long-Chain Polyunsaturated Fatty Acids in Pregnant Women and Their Newborns: Data from Three European Countries [PDF]

, 2011
Background: trans unsaturated fatty acids are thought to interfere with essential fatty acid metabolism. To extend our knowledge of this phenomenon, we investigated the relationship between trans isomeric and long-chain polyunsaturated fatty acids ...
B. Koletzko, Bakker EC, Birch EE, Bouwstra H, C. Campoy, Chen IA, Decsi T, Decsi T, Decsi T, Dirix CE, Dirix CE, Donahue SM, Elias SL, Farquharson J, Franke C, G. Marchal, H. Demmelmair, Harvey KA, Helland IB, Jendryczko A, Koletzko B, Koletzko B, Krauss-Etschmann S, Kummerow FA, Lemaitre RN, L’Abbé MR, M. Cruz, M. Escolano, Mahfouz MM, Mahfouz MM, Makrides M, Morrison JA, Mozaffarian D, Parra MS, Roach C, S. Krauss-Etschmann, Sun Q, Szabó, Szabó, T. Decsi, T. Marosvölgyi, Thomas RM, van Eijsden M, van Houwelingen AC, É. Szabó   +44 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Lipid\'s three-dimensional molecular changes in cellular membrane and its relation with Endocytosis and Exocytosis

مجله دانشگاه علوم پزشکی گرگان, 1999
All the Lipids within the cellular membranes are existed in bilayer structure, but it has been proved that when some of these Lipids extracted from the native membrane and dispersed in water, it does exhibit non-bilayer structure, although the same ...
Mansourian AR (PhD), Saifi A (Pharm.D)
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Molecular rheometry: direct determination of viscosity in L-o and L-d lipid phases via fluorescence lifetime imaging [PDF]

, 2013
Understanding of cellular regulatory pathways that involve lipid membranes requires the detailed knowledge of their physical state and structure. However, mapping the viscosity and diffusion in the membranes of complex composition is currently a non ...
Agnieszka Olzyńska, Akashi, Alamiry, Benda, Beranova, Capoulade, Chen, Dertinger, Duncan R. Casey, Eggeling, Förster, Gokhan Yahioglu, Haidekker, Haidekker, Hoekstra, Hope, Ikonen, Jana Humpolíčková, Kahya, Kuimova, Kuimova, Kuimova, Levitt, Marina K. Kuimova, Martin Hof, Martin Štefl, Oscar Ces, Pan, Petrov, Philip Yip, Saffman, Sankaran, Schutz, Smith, Sykora, Veatch, Wohland, Yilei Wu   +37 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

Journal of Structural Biology: X
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane proteins, individual ...
Evan J. van Aalst, Maryam Yekefallah, Roy A. M. van Beekveld, Eefjan Breukink, Markus Weingarth, Benjamin J. Wylie   +5 more
doaj   +1 more source

Fluorescent Lipids: Functional Parts of Fusogenic Liposomes and Tools for Cell Membrane Labeling and Visualization

Molecules, 2012
In this paper a rapid and highly efficient method for controlled incorporation of fluorescent lipids into living mammalian cells is introduced. Here, the fluorescent molecules have two consecutive functions: First, they trigger rapid membrane fusion ...
Christian Kleusch, Bernd Hoffmann, Nils Hersch, Agnes Csiszár, Rudolf Merkel   +4 more
doaj   +1 more source