Results 61 to 70 of about 433,130 (308)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

High‐Speed Atomic Force Microscopy Reveals the Dynamic Interplay of Membrane Proteins is Lipid‐Modulated

Small Science
The solvent of membrane proteins is the membrane lipids in which they are embedded. Therefore, the nature of the lipids that surround membrane proteins impacts their dynamics and interactions.
Eunji Shin, Yining Jiang, Batiste Thienpont, James N Sturgis, Simon Scheuring   +4 more
doaj   +1 more source

Introducing Membrane Charge and Membrane Potential to T Cell Signaling

Frontiers in Immunology, 2017
While membrane models now include the heterogeneous distribution of lipids, the impact of membrane charges on regulating the association of proteins with the plasma membrane is often overlooked.
Yuanqing Ma, Yuanqing Ma, Kate Poole, Kate Poole, Jesse Goyette, Jesse Goyette, Katharina Gaus, Katharina Gaus   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The effect of membrane active agents on human leukaemia cells [PDF]

, 1998
This Thesis investigates the effect of membrane-active agents, such as synthetic ether lipids (SEL), local anaesthetics and polyunsaturated fatty acids (PUFAs) on human leukaemia cells.
Jones, Eirian Wynne
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Lipid-itraconazole Interaction in Lipid Model Membranes

Journal of Pharmacy and Pharmacology, 1991
Abstract Itraconazole, a lipophilic, fungal sterol-biosynthesis inhibitor, does not disturb membrane organization parameters measured by differential scanning calorimetry and infrared spectroscopy. Conformational analysis studies suggest that the molecular volume and the position of itraconazole in the lipid membrane is similar to that ...
Brasseur, Robert, Goormaghtigh, Erik, Ruysschaert, Jean Marie, Duquenoy, Philippe, Marichal, P, Vanden Bossche, H   +5 more
openaire   +3 more sources

Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids

, 2021
The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk samples, and infant milk intake were collected in a cohort of eleven healthy mother–infant dyads during exclusive breastfeeding ...
Alexandra D. George, Jayashree Selvalatchmanan, Wlodek, Mary E., Selvalatchmanan, Jayashree, George, Alexandra D., Mary E. Wlodek, Donna T. Geddes, Geddes, Donna T., Markus R. Wenk, Bendt, Anne K., Murray, Kevin, Anne K. Bendt, Federico Torta, Wenk, Markus R., Melvin C. L. Gay, Kevin Murray, Torta, Federico, Gay, Melvin C. L.   +17 more
core   +1 more source

Role of Oxidized Lipids in Permeation of H2O2 Through a Lipid Membrane: Molecular Mechanism of an Inhibitor to Promoter Switch

Scientific Reports, 2019
H2O2 permeation through a cell membrane significantly affects living organisms, and permeation is controlled by the physico-chemical nature of lipids and other membrane components.
Yuya Ouchi, Kei Unoura, Hideki Nabika
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source