Results 101 to 110 of about 232,617 (270)

ExPortal and the LiaFSR Regulatory System Coordinate the Response to Cell Membrane Stress in Streptococcus pyogenes

mBio, 2020
LiaFSR is a gene regulatory system important for response to cell membrane stress in Gram-positive bacteria but is minimally studied in the important human pathogen group A Streptococcus (GAS). Using immunofluorescence and immunogold electron microscopy,
Yibin Lin, Misu A. Sanson, Luis Alberto Vega, Brittany Shah, Shrijana Regmi, M. Belen Cubria, Anthony R. Flores   +6 more
doaj   +1 more source

Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism [PDF]

, 2017
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Albi, Elisabetta, AMBESI IMPIOMBATO, Francesco Saverio, Bartoccini, Elisa, Beccari, Tommaso, Cascianelli, Giacomo, Cataldi, Samuela, Ceccarini, Maria Rachele, Codini, Michela, Curcio, Francesco, Floridi, Alessandro, Lazzarini, Andrea   +10 more
core   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Molecular dynamics exploration of poration and leaking caused by Kalata B1 in HIV-infected cell membrane compared to host and HIV membranes

Scientific Reports, 2017
The membrane disruption activities of kalata B1 (kB1) were investigated using molecular dynamics simulations with membrane models. The models were constructed to mimic the lipid microdomain formation in membranes of HIV particle, HIV-infected cell, and ...
Wanapinun Nawae, Supa Hannongbua, Marasri Ruengjitchatchawalya   +2 more
doaj   +1 more source

Lipid rafts: The enigmatic membrane microdomain [PDF]

The Biochemist, 2009
In the field of membrane biology, perhaps one of the most controversial concepts in recent years has been the enigmatic membrane microdomain, the cholesterol- and glycosphingolipid-rich lipid raft.
David R. Taylor, Nigel M. Hooper
openaire   +1 more source

Insulin Signaling in Microdomains of the Plasma Membrane [PDF]

Traffic, 2003
Although the effects of insulin on glucose and lipid metabolism are well documented, gaps remain in our understanding of the precise molecular mechanisms of signal transduction. Recent evidence suggests that compartmentalization of signaling molecules and metabolic enzymes may explain the unique cellular effects of the hormone.
Saltiel, Alan R., Pessin, Jeffrey E.
openaire   +3 more sources

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

Journal of Structural Biology: X
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane proteins, individual ...
Evan J. van Aalst, Maryam Yekefallah, Roy A. M. van Beekveld, Eefjan Breukink, Markus Weingarth, Benjamin J. Wylie   +5 more
doaj   +1 more source

Contributions of quantitative proteomics to understanding membrane microdomains

Journal of Lipid Research, 2009
Membrane microdomains, e.g., lipid rafts and caveolae, are crucial cell surface organelles responsible for many cellular signaling and communication events, which makes the characterization of their proteomes both interesting and valuable. They are large
Yu Zi Zheng, Leonard J. Foster
doaj   +1 more source

The trafficking and targeting of P2X receptors [PDF]

, 2013
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D, Robinson, Lucy E   +1 more
core   +3 more sources