Results 111 to 120 of about 232,617 (270)

EGF induces rapid reorganization of plasma membrane microdomains [PDF]

Communicative & Integrative Biology, 2009
The plasma membrane of mammalian cells is composed of a great variety of different lipids which are laterally organized into lipid domains. The segregation of lipids into domains has been studied in great detail in vesicles but domain formation of lipids in the plasma membrane of live cells is still unclear.
Hofman, E.G., Bader, A.N., Gerritsen, H.C., van Bergen en Henegouwen, P.M.P.   +3 more
openaire   +3 more sources

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

Advanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen, Bin Li, Yingying Wang, Fulin Zhu, Wenxuan Yang, Xuanyu Fu, Tiantian Man, Qiuyue Wu, Kewei Ren, Shengyuan Deng   +9 more
wiley   +1 more source

The membrane matters: Plasma membrane composition shapes MRGPRX2-driven immune responses [PDF]

Exploration of Asthma & Allergy
The composition and biophysical characteristics of the plasma membrane are pivotal in regulating mast cell immune functions by influencing receptor distribution, activation, and intracellular signaling pathways.
Liron Lerner, Magda Babina, Torsten Zuberbier, Katarina Stevanovic   +3 more
doaj   +1 more source

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. [PDF]

, 2015
Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins.
Balogh, Gábor, Busquets, Xavier, Escribá, Pablo V., Harwood, John L., Horváth, Ibolya, Inokuchi, Jin-ichi, Török, Zsolt, Vígh, László   +7 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [PDF]

, 2010
The dynamin-related GTPase OPA1 is mutated in autosomal dominant optic atrophy (DOA) (Kjer type), an inherited neuropathy of the retinal ganglion cells.
Alexander, Amati-Bonneau, Ardail, David C. Chan, Delettre, Delettre, Detmer, DeVay, Frezza, Griparic, Herlan, Heymann, Hudson, Ingerman, Jenny E. Hinshaw, Jürgen A.W. Heymann, Leonard, Meeusen, Olichon, Praefcke, Pucadyil, Rujiviphat, Sesaki, Song, Song, Tadato Ban, Tondera, Zhiyin Song, Zick   +28 more
core   +3 more sources

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment

Journal of Lipid Research, 2004
P-glycoprotein (P-gp) appears to be associated within specialized raftlike membrane microdomains. The activity of P-gp is sensitive to its lipid environment, and a functional association in raft microdomains will require that P-gp retains activity in the
Szabolcs Modok, Catherine Heyward, Richard Callaghan   +2 more
doaj   +1 more source

Manipulation of lipid rafts in neuronal cells [PDF]

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core   +1 more source

Creating and Modulating Microdomains in Pore‐Spanning Membranes

ChemPhysChem, 2011
AbstractThe architecture of the plasma membrane is not only determined by the lipid and protein composition, but is also influenced by its attachment to the underlying cytoskeleton. Herein, we show that microscopic phase separation of “raft‐like” lipid mixtures in pore‐spanning bilayers is strongly determined by the underlying highly ordered porous ...
Orth, Alexander, Ludger, Johannes, Römer, Winfried, Steinem, Claudia   +3 more
openaire   +4 more sources