Results 91 to 100 of about 29,523 (243)

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. [PDF]

, 2019
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the ...
Clanton, Joshua A, Cronan, Mark R, Jiang, Nan, Kim, Hyeon-Jin, Luedke, Kory P, Parker, Edward D, Parrish, Jay Z, Rasmussen, Jeffrey P, Rosenberg, Marci F, Sagasti, Alvaro, Vaughan, Joshua C   +10 more
core  

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies [PDF]

, 2013
Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Abe, Abrami, Bhown, Bokori-Brown, Chassin, Cole, Davis, De Colibus, Diep, Dorca-Arevalo, Emsley, Finnie, Ivie, Ivie, Jin, Knight, Lavinder, Lonchamp, McClain, McCoy, McDonel, Minami, Miyamoto, Miyamoto, Miyata, Murshudov, Nagahama, Nagahama, Nagahama, Oyston, Parker, Payne, Pelish, Petit, Pflugrath, Popoff, Popoff, Recommendations of the CDC Strategic Planning Workgroup, Songer, Uzal, Winn   +40 more
core   +1 more source

Microdomain Organization of the Plasma Membrane in Keratinocytes [PDF]

The Open Dermatology Journal, 2009
Plasma membrane of the keratinocyte is organized in a domain structure comprising the nanoscale areas of the lipid in the liquid ordered state (comparable to lipid rafts) surrounded by the liquid-disordered lipid fraction. In this review we summarize the current state of knowledge on the microdomain organization of the keratinocytes plasma membrane ...
Vind-Kezunovic, D., Gniadecki, R.
openaire   +2 more sources

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Receptor Tyrosine Kinases — Expanding Horizons

Cells, 2014
This Special Issue of Cells on receptor tyrosine kinases (RTKs) is a timely and unique assemblage of scholarly insights into topics that have relatively recently entered the spotlight in relation to this class of molecules. The review by Julien et al. [1]
Sassan Hafizi
doaj   +1 more source

A novel mutation in isoform 3 of the plasma membrane Ca2+ pump impairs cellular Ca2+ homeostasis in a patient with cerebellar ataxia and laminin subunit 1\u3b1 mutations. [PDF]

, 2015
The particular importance of Ca2+ signaling to neurons demands its precise regulation within their cytoplasm. Isoform 3 of the plasma membrane Ca2+ ATPase (the PMCA3 pump), which is highly expressed in brain and cerebellum, plays an important role in the
Brini, Marisa, Cali', Tito, Carafoli, Ernesto, Frizzarin, Martina, Lopreiato, Raffaele, Shimony, J, Shinawi, M, Vineyard, M, Zanni, G, Zanotti, Giuseppe   +9 more
core   +1 more source

Dynamic composition of membrane microdomains [PDF]

, 2012
Lipid rafts are cholesterol enriched membrane microdomains involved in many cellular functions. Caveolae are a sub-type of lipid rafts that are smooth invaginations of the plasma membrane (PM) whose formation requires caveolin-1 (Cav1). Here, we determined the lipid rafts and caveolae proteome from various cells in an unbiased manner and examined the ...
openaire   +1 more source

Ceramide-enriched microdomains in planar membranes

Current Opinion in Colloid & Interface Science, 2010
Ceramide has a large effect on the properties of biological membranes, increasing lipid order and promoting lateral phase separation, and plays an important role in cell signaling. This review provides an overview of recent studies of the effects of direct ceramide incorporation and enzymatic ceramide generation on planar supported membranes, including
Zou, Shan, Johnston, Linda J.
openaire   +4 more sources

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source