Results 101 to 110 of about 1,117,893 (276)

Synaptic membrane proteins form stable microdomains in early endosomes.

, 2009
In the plasma membrane, membrane proteins are frequently organized in microdomains that are stabilized both by protein-protein and protein-lipid interactions, with the membrane lipid cholesterol being instrumental for microdomain stability.
Schaefer, C., Jahn, R., Geumann, Ulf, Jahn, Reinhard, Riedel, D., Riedel, Dietmar, Rizzoli, Silvio, Geumann, U., Rizzoli, S., Schaefer, Christina, Rizzoli, S. O.   +10 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM).

PLoS ONE, 2019
Membrane microdomains or lipid rafts compartmentalize cellular processes by laterally organizing membrane components. Such sub-membrane structures were mainly described in eukaryotic cells, but, recently, also in bacteria.
José E Guzmán-Flores, Lidia Steinemann-Hernández, Luis E González de la Vara, Marina Gavilanes-Ruiz, Tony Romeo, Adrián F Alvarez, Dimitris Georgellis   +6 more
doaj   +1 more source

Lipid microdomains in cell surface membranes

Current Opinion in Structural Biology, 1997
Lipid microdomains within cell membranes are detected by a variety of experimental techniques, each of which characterizes microdomains on a different time and spatial scale. The sum of the data on lipid microdomains has yet to be integrated into a single model of cell membrane structure.
openaire   +2 more sources

Solubilization of lipids and membrane proteins into nanodiscs: Mode of action and applications of SMA copolymers [PDF]

, 2016
Cell membranes separate the inside and outside of cells. Membrane proteins in the cell membrane control the traffic of molecules across the membrane and are therefore targets for a lot of drugs: about 50 % of all approved drugs target a membrane protein!
Scheidelaar, S., Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics   +2 more
core  

Interferon-gamma and tumor necrosis factor-alpha disrupt epithelial barrier function by altering lipid composition in membrane microdomains of tight junction

, 2008
Tight junctions (TJs) are specialized membrane microdomains of plasma membrane and play an important role in barrier function. IFN-gamma and TNF-alpha have been implicated in intestinal barrier dysfunction. In the present study, we analyzed the effect of
Li, Ning, Zhao, Sumin, Qiang Zhang, Zhang, Qjang, Jieshou Li, Ma, Jian, Nan Luo, Guowang Xu, Wang, Meng, Sumin Zhao, Jian Ma, Qiurong Li, Yousheng Li, Luo, Nan, Ning Li, Li, Qiurong, Meng Wang, Li, Yousheng, Li, Jieshou, 黎介寿, Xu, Guowang   +20 more
core   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Coassembly of Flotillins Induces Formation of Membrane Microdomains, Membrane Curvature, and Vesicle Budding [PDF]

, 2007
SummaryEndocytosis has a crucial role in many cellular processes. The best-characterized mechanism for endocytosis involves clathrin-coated pits [1], but evidence has accumulated for additional endocytic pathways in mammalian cells [2].
Merrified, Christien, Bright, Nicholas A., Frick, Manfred, Riento, Kirsi, Bray, Aurélie, Nichols, Benjamin J.   +5 more
core   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source