Results 141 to 150 of about 29,208 (221)

Spherulite in the modern aragonitic travertine stromatolite has a calcite core with exopolymers

Sedimentology, EarlyView.
ABSTRACT Spherulites are spherical to ellipsoidal particles formed by various crystalline substances and can be abiotically synthesised in the laboratory. Among various spherulite types, spherulites composed of calcium carbonate are also found in various natural environments, but their abiotic or biotic origins are still controversial.
Fumito Shiraishi, Takayuki Akimoto, Naotaka Tomioka, Satoko Motai, Yoshio Takahashi   +4 more
wiley   +1 more source

Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections. [PDF]

Cell Rep, 2020
Schmidt F, Thywißen A, Goldmann M, Cunha C, Cseresnyés Z, Schmidt H, Rafiq M, Galiani S, Gräler MH, Chamilos G, Lacerda JF, Campos A, Eggeling C, Figge MT, Heinekamp T, Filler SG, Carvalho A, Brakhage AA.   +17 more
europepmc   +1 more source

Structure mirroring function: What's the ‘matter’ with the funny current?

The Journal of Physiology, EarlyView.
Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion. [PDF]

Langmuir, 2020
Barros M, Houlihan WJ, Paresi CJ, Brendel M, Rynearson KD, Lee CW, Prikhodko O, Cregger C, Chang G, Wagner SL, Gilchrist ML, Li YM.   +11 more
europepmc   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy. [PDF]

Am J Physiol Heart Circ Physiol
Zemljic-Harpf AE, Bonds JA, Zuniga-Hertz JP, Patel HH.   +3 more
europepmc   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Membrane microdomains are crucial for <i>Mycobacterium marinum</i> EsxA-dependent membrane damage, escape to the cytosol, and infection. [PDF]

Sci Adv
Perret A, Bosmani C, Leuba F, Eblighatian K, Guého A, Raykov L, Hanna N, Soldati T.   +7 more
europepmc   +1 more source