Results 151 to 160 of about 29,523 (243)

The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane [PDF]

open access: hybrid, 2001
Heidi E. Karpen   +5 more
openalex   +2 more sources

Short‐Term Bienenstock‐Cooper‐Munro Learning in Optoelectrically‐Driven Flexible Halide Perovskite Single Crystal Memristors

open access: yesSmall Methods, EarlyView.
This paper presents a flexible CsPbBr3 perovskite memristor with synaptic behavior, which is in accordance with the Bienenstock‐Cooper‐Munro (BCM) theory of cortical plasticity, realized directly, similarly to biological experiments. Additionally, this effect can be modulated by visible light, within the framework of BCM theory.
Ivan Matchenya   +15 more
wiley   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

open access: yes, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

Computational Astrocyence: Astrocytes encode inhibitory activity into the frequency and spatial extent of their calcium elevations

open access: yes, 2019
Deciphering the complex interactions between neurotransmission and astrocytic $Ca^{2+}$ elevations is a target promising a comprehensive understanding of brain function.
Ivanov, Vladimir A.   +2 more
core   +1 more source

Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise

open access: yesAging Cell, EarlyView.
Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise. ABSTRACT Sarcopenia, or age‐related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast‐to‐slow fiber type switching, which is typically secondary to
Ryan J. Allen   +9 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

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