Results 141 to 150 of about 1,117,893 (276)

Insights into membrane solubilization by styrene-maleic acid copolymers [PDF]

, 2018
Styrene-and-maleic acid copolymers (SMA) are gaining interest in membrane protein research due to their ability of solubilizing lipid membranes into nanodiscs.
Dominguez Pardo, J.J., Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics   +2 more
core  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility. [PDF]

Commun Biol, 2021
Olivieri A, Lee RS, Fratini F, Keutcha C, Chaand M, Mangano V, Celani F, Mochi S, Birago C, Paone S, Grasso F, Tirelli V, Falchi M, Shabani E, Bertoncini S, Sirima BS, Pizzi E, Modiano D, Duraisingh MT, Ponzi M.   +19 more
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

NbSOBIR1 Partitions Into Plasma Membrane Microdomains and Binds ER-Localized NbRLP1. [PDF]

Front Plant Sci, 2021
Li YH, Ke TY, Shih WC, Liou RF, Wang CW.
europepmc   +1 more source

Dynamic composition of membrane microdomains

, 2012
Lipid rafts are cholesterol enriched membrane microdomains involved in many cellular functions. Caveolae are a sub-type of lipid rafts that are smooth invaginations of the plasma membrane (PM) whose formation requires caveolin-1 (Cav1). Here, we determined the lipid rafts and caveolae proteome from various cells in an unbiased manner and examined the ...
openaire   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques?

Membranes
Lipid rafts are dynamic microdomains in the membrane, rich in cholesterol and sphingolipids, that are critical for biological processes like cell signalling, membrane trafficking, and protein organization.
Sara Anselmo, Elisa Bonaccorso, Chiara Gangemi, Giuseppe Sancataldo, Valeria Conti Nibali, Giovanna D’Angelo   +5 more
doaj   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

Small, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa, Lorenzo Arnaboldi, Veronica De Giorgis, Marco Ghirimoldi, Elettra Barberis, Marco Brucale, Francesco Valle, Mario Malerba, Marta Vallino, Angelo Musicò, Roberto Frigerio, Alessandro Gori, Vera Mugoni, Claudia Voena, Roberto Pisano, Fabrizio Pirri, Silvia Arpicco, Marcello Manfredi, Tania Limongi   +18 more
wiley   +1 more source