Results 191 to 200 of about 29,523 (243)

A Microdomain-Structured Synthetic High-Flux Hollow-Fiber Membrane for Renal Replacement Therapy

, 2000
Nicholas A. Hoenich, S Stamp, Sarah J. Roberts   +2 more
openalex   +1 more source

Identification of c‐Met on Tumor Cells as a Novel Receptor for B7‐H3 Entails Implications for Cancer Cell Stemness and Targeted Therapy

MedComm, Volume 6, Issue 9, September 2025.
B7‐H3 and c‐Met interaction is revealed to be crucial in maintaining cancer cell stemness primarily via c‐Met/STAT3 signaling pathway. B7‐H3 antibody blocking this newly identified interaction exhibits preclinical effects as a new and potent intervention for molecular targeted therapy.
Lei Cao, Yunyun Xu, Yizhou Hu, Xue Huang, Fengqing Fu, Shenghua Zhan, Lili Huang, Yangyang Feng, Ylivinkka Irene, Huini Li, Varjosalo Markku, Keski‐Oja Jorma, Guangbo Zhang, Binfeng Lu, Jian Wang, Wanli Liu, Xueguang Zhang   +16 more
wiley   +1 more source

Cholesterol depletion uncouples the cholera toxin (CT)-GM1 complex from signal transduction and disrupts protein content of detergent-insoluble membrane microdomains (DIGs) in polarized T84 cells

, 2000
Anne A. Wolf, Wayne I. Lencer
openalex   +1 more source

Association of GM3 with Zap-70 Induced by T Cell Activation in Plasma Membrane Microdomains [PDF]

, 2002
Tina Garofalo, Luisa Lenti, Agostina Longo, Roberta Misasi, Vincenzo Mattei, G. M. Pontieri, Maurizio Sorice, Antonio Pavan   +7 more
openalex   +1 more source

Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu, Shanshan Yang, You Zhang, Zhiguang Su   +3 more
wiley   +1 more source

Metabolic labelling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor [PDF]

, 2002
Alexandre K. Rouquette‐Jazdanian, Claudette Pelassy, Jean‐Philippe Breittmayer, Jean‐Louis Cousin, Claude Aussel   +4 more
openalex   +1 more source

Analysis of Population Structure and Selection Signatures in Two Iraqi Fat‐Tailed Sheep Breeds

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Awassi sheep exhibit clear genetic separation, whereas Hamdani sheep show an admixed profile, with iHS, ROH and Tajima's D analyses identifying breed‐specific candidate genes. Enrichment in immune response, hormone regulation and cellular signalling pathways highlights adaptive evolution and guides future breeding and conservation.
Mervan Bayraktar, Omer Shoshin, K. A. Saravanan, Tahreer M. Al‐Thuwaini, Gökhan Gökçe, Zeynab Hussein Fadhil, Melis Çelik Güney   +6 more
wiley   +1 more source

Multimerization of Human Immunodeficiency Virus Type 1 Gag Promotes Its Localization to Barges, Raft-Like Membrane Microdomains

, 2001
O. Wolf Lindwasser, Marilyn D. Resh
openalex   +1 more source

Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK [PDF]

, 2003
Amy M. Navratil, Stuart P. Bliss, Kathie A. Berghorn, James M. Haughian, Todd A. Farmerie, James K. Graham, Colin M. Clay, Mark S. Roberson   +7 more
openalex   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, Volume 182, Issue 18, Page 4327-4342, September 2025.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source