Results 61 to 70 of about 628,659 (381)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Direct observation of defects and increased ion permeability of a membrane induced by structurally disordered Cu/Zn-superoxide dismutase aggregates. [PDF]
PLoS ONE, 2011 Interactions between protein aggregates and a cellular membrane have been strongly implicated in many protein conformational diseases. However, such interactions for the case of Cu/Zn superoxide dismutase (SOD1) protein, which is related to fatal ...
Inhee Choi +8 more
doaj +1 more source
A Synthetic Model of the Mucosa for Oral Penetration Studies
Membranes, 2023 The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa.
Cristina Alonso +5 more
doaj +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Effect of Heat Treatment in Air on Hydrogen Permeation Through Pd Membrane
He huaxue yu fangshe huaxueIn order to study the effect of heat treatment in air on the hydrogen permeation in/through Pd membrane, Pd membrane was deposited via the electroless plating method and the hydrogen permeation flux of Pd membrane before and after heat treatment in air ...
YIN Zhao-hui +5 more
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Neuronal Plasma Membrane Integrity is Transiently Disturbed by Traumatic Loading
Neuroscience Insights, 2020 The acute response of neurons subjected to traumatic loading involves plasma membrane disruption, yet the mechanical tolerance for membrane compromise, time course, and mechanisms for resealing are not well understood.
Gustavo R Prado, Michelle C LaPlaca
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Membranes, 2022 The performance of a desalination membrane depends on a specific pore size suitable for both water permeability and salt rejection. To increase membrane permeability, the applied pressure should be increased, which creates the need to improve membrane ...
Qusai Ibrahim +3 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Molecules, 2015 In the present investigation we studied the molecular mechanisms of the monodesmosidic saponin digitonin on natural and artificial membranes. We measured the hemolytic activity of digitonin on red blood cells (RBCs). Also different lipid membrane models (
Ikhwan Resmala Sudji +4 more
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Lysosome membrane permeability to anions
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1998 The permeability of rat liver lysosomes to some inorganic and aliphatic organic anions was investigated, using an osmotic-protection methodology. Lysosomes were incubated at 25 degreesC in 250 mOsm solutions of potassium salts of the anions, in the presence of valinomycin, and the latency of lysosomal hexosaminidase measured at intervals.
Ann R. Klemm +4 more
openaire +3 more sources