Results 101 to 110 of about 3,357,590 (333)

Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]

, 1996
The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk,, Brands, Jan Roel,, Driessen, Arnold J.M.,, Konings, Wil N.,, Poolman, Bert,, Putman, Monique,, Veen, Hendrik W. van,   +6 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Attractive asymmetric inclusions in elastic membranes under tension: cluster phases and membrane invaginations

, 2013
Up-down asymmetric inclusions impose a local, spontaneous curvature to an elastic membrane. When several of them are inserted in a same membrane, they feel effective forces mediated by the membrane, both of elastic and entropic nature.
Destainville, Nicolas, Weitz, Sebastian
core   +3 more sources

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
A Degterev, A Müller, A Müller, AE Deghmane, Anke Harsman, B Shanmugavadivu, Dirk Günther, DM Walther, DR Voelker, E Gottlieb, E Gottlieb, Elke A. Dian-Lothrop, Eva Hauf, FJ Bauer, FJ Castora, G Kroemer, G Schatz, Hank Steven Seifert, I Guilvout, IE Gentle, Ines Herrmann, J Song, JE Chipuk, JF Weel, Joachim Rassow, K Hill, Katharina Ross, Krishnaraj Rajalingam, L Scorrano, LA Pon, LC Armstrong, LM Loew, M Meinecke, MC Wei, Michael Meinecke, MP Bos, N Bolender, N Pfanner, N Wiedemann, N Wiedemann, O Kepp, O Kepp, Oliver Kepp, P Massari, P Massari, P Mueller, R Voulhoux, RD Taylor, Richard Wagner, Robert Hurwitz, RP Zahedi, S Desagher, S Kutik, S Makino, SA Paschen, SA Paschen, T Krimmer, T Rudel, Thomas Rudel, V Kozjak, V Kozjak-Pavlovic, V Robert, Vera Kozjak-Pavlovic, Volker Brinkmann, W Neupert   +64 more
core   +4 more sources

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Six principles of visual cortical dynamics

Frontiers in Systems Neuroscience, 2010
A fundamental goal in vision science is to determine how many neurons in how many areas are required to compute a coherent interpretation of the visual scene.
Per E Roland
doaj   +1 more source

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

, 2006
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet, C. C. A. M. Gielen, D. L. Ypey, J. Guckenheimer, J. M. A. M. Kusters, J. M. Cortes, J. D. Murray, O. Aslanidi, T. R. Chay, W. P. M. van Meerwijk   +9 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source