Results 111 to 120 of about 228,598 (287)

Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels.

PLoS Biology
Fast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders.
Léa Demesmay, Romane Idoux, Christine Berthier, Claire Bernat, Léon Espinosa, Vincent Jacquemond, Frédéric Brunet, Angel Maunier-Mercier, Philippe Lory, Sophie Nicole, Bruno Allard   +10 more
doaj   +1 more source

Impaired thalamic burst firing in fragile X syndrome

Cell Reports
Summary: The thalamus performs a critical role in sensory processing by gating the flow of sensory information to the neocortex and directing sensory-guided behaviors, functions that are disrupted in people with autism spectrum disorder (ASD).
Ronan T. O’Shea, Nicholas J. Priebe, Darrin H. Brager   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Membrane potential and resistance measurement in acinar cells from salivary glands in vitro: effect of acetylcholine [PDF]

, 1974
Akira Nishiyama, Ole H. Petersen
openalex   +1 more source

Polymeric Microfiltration Membranes Modification by Supercritical Solvent Impregnation—Potential Application in Open Surgical Wound Ventilation [PDF]

, 2021
Mariusz Nowak, Dušan Mišić, A. Trusek-Hołownia, Irena Žižović   +3 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A nonlinear coupling between the firing threshold and the membrane potential enhances coding of rapid signals

, 2013
Pozzorini Christian, Skander Mensi, Olivier Hagens, Gerstner Wulfram   +3 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Roles Played by Critical Potentials in the Study of Poisson–Nernst–Planck Models with Steric Effects Under Relaxed Neutral Boundary Conditions

Axioms
We examine the qualitative properties of ionic flows through membrane channels via Poisson–Nernst–Planck (PNP) type models with steric effects under relaxed electroneutrality boundary conditions, and more realistic setups in the study of ion channel ...
Xiangshuo Liu, Jie Song, Lijun Zhang, Mingji Zhang   +3 more
doaj   +1 more source