Results 191 to 200 of about 4,442,719 (304)

VPS26A retromer complex and SNX27 mediate stress-induced Golgi bypass of membrane proteins. [PDF]

Nat Commun
Kim YJ, Lee C, Seo SK, Roh JW, Lee HR, Hwang SJ, Chang N, Choi HS, Shin DH, Kim HK, Kim HS, Cho HS, Cho HS, Lee JM, Gee HY, Lee MG, Noh SH.   +16 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Loss of peroxisomal membrane proteins PEX13 and PEX14 disrupts fatty acid oxidation and drives lipid imbalance. [PDF]

Biosci Rep
Vinoy N, Huang G, Wallace D, Subramaniam VN.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Dual-Color Expansion Microscopy of Membrane Proteins Using Bioorthogonal Labeling. [PDF]

Nano Lett
Edwards S, Meineke B, Bauer S, Blom H, Elsässer S, Brismar H.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Structural insights into MERS and SARS coronavirus membrane proteins. [PDF]

Commun Biol
Mann MK, Yin Y, Marsili S, Xie J, Doijen J, Miller R, Piassek M, van den Broeck N, Kariuki CK, de Gruyter HLM, Leijs AA, Snijder EJ, van Hemert MJ, Keustermans K, Van Gool M, Yu X, Loock MV, Koul A, Sharma S, Van Damme E, Abeywickrema P.   +20 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Multiple novel membrane proteins involve phthalate ester degradation in <i>Rhodococcus</i> sp. AH-ZY2. [PDF]

Appl Environ Microbiol
Hou Z, Pan H, Wang S, Li Y, Yu Y, Qiao P, Wang H, Zhong W.   +7 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source