Results 211 to 220 of about 10,936,171 (356)

Membrane-embedded polar residues target membrane proteins for degradation by the quality control protease FtsH. [PDF]

Nat Commun
Chai-Danino M, Ravensary-Modin N, Vladimirov VI, Onyshchuk T, Plöhn M, Barshap ABD, Bsoul A, Peled-Zehavi H, Fluman N.   +8 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins.

Journal of the American Chemical Society, 2013
F. Hagn, M. Etzkorn, Thomas Raschle, G. Wagner   +3 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

An Overview of Target Membrane Proteins for Near-Infrared Photoimmunotherapy. [PDF]

Pharmaceuticals (Basel)
Suzuki M, Hanaoka H.
europepmc   +1 more source

Structure and function of bacterial outer membrane proteins: barrels in a nutshell

Molecular Microbiology, 2000
R. Koebnik, K. Locher, P. Van Gelder
semanticscholar   +1 more source

Membrane protein structure

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002
Yeagle, Philip L., Lee, Dr.A.G.
openaire   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Erratum to "Integrated Single-Step Terahertz Metasensing for Simultaneous Detection Based on Exosomal Membrane Proteins Enables Pathological Typing of Gastric Cancer". [PDF]

Research (Wash D C)
Jia Q, Ma Z, Wang Y, Zhang M, Zou G, Lan B, Li S, Lao Z, Shen W, Lou J, Jiao Y, Du X.   +11 more
europepmc   +1 more source

Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.

Annual Review of Biophysics and Biophysical Chemistry, 1986
D. Engelman, T. Steitz, A. Goldman
semanticscholar   +1 more source