Results 221 to 230 of about 4,599,169 (256)

Energy Landscape Analysis of Membrane Proteins Using NMR-Based Hybrid Restraint Potentials. [PDF]

J Chem Theory Comput
Dewan D, Wang Y, De Simone A, Wales DJ.
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Visualization of lysosomal membrane proteins by cryo electron tomography. [PDF]

Nat Commun
McVeigh BM, De Jesús-Pérez JJ, Siepe DH, Gogoi P, Mageswaran SK, Kalocsay M, Mihelc EM, Moiseenkova-Bell VY.   +7 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy. [PDF]

Adv Sci (Weinh)
Zhao X, Zhou Q, Li M, Zou W, Zhang Z, Shi J, Liu J.   +6 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Pseudovirus-mediated proximity labeling identifies candidate host cell membrane proteins involved in viral attachment. [PDF]

J Virol
Kotani N, Iwasa K, Amimoto T, Yamashita C, Komatsu K, Narimichi Y, Wakabayashi Y, Kurebayashi Y, Horiuchi Y, Kashimata L, Sasaki R, Kumagai M, Yagishita-Kyo N, Awaji T, Murakami T, Mizuno Y, Nakano M, Takahashi T, Takeuchi H, Honke K.   +19 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Functional diversity and molecular interactions of small membrane proteins in bacteria. [PDF]

Microlife
Yuan J, Koch HG, Berghoff BA.
europepmc   +1 more source