Results 201 to 210 of about 9,896,950 (388)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Visualization of lysosomal membrane proteins by cryo electron tomography. [PDF]

Nat Commun
McVeigh BM, De Jesús-Pérez JJ, Siepe DH, Gogoi P, Mageswaran SK, Kalocsay M, Mihelc EM, Moiseenkova-Bell VY.   +7 more
europepmc   +1 more source

Merging In-Solution X-ray and Neutron Scattering Data Allows Fine Structural Analysis of Membrane–Protein Detergent Complexes

, 2018
Gaëtan Dias Mirandela, Giulia Tamburrino, Miloš T. Ivanović, Felix Strnad, Olwyn Byron, Tim Rasmussen, Paul A. Hoskisson, Jochen S. Hub, Ulrich Zachariae, Frank Gabel, Arnaud Javelle   +10 more
openalex   +1 more source

Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei

, 2020
Megan E. Grund, Soo Jeon Choi, Dudley H. McNitt, Mariette Barbier, Gangqing Hu, P. Rocco LaSala, Christopher K. Cote, Rita Berisio, Sławomir Łukomski   +8 more
openalex   +2 more sources

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

Nature Protocols, 2014
A. Goehring, Chia-Hsueh Lee, Kevin H. Wang, J. C. Michel, D. P. Claxton, I. Baconguis, Thorsten Althoff, Suzanne Fischer, K. Garcia, E. Gouaux   +9 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Functional diversity and molecular interactions of small membrane proteins in bacteria. [PDF]

Microlife
Yuan J, Koch HG, Berghoff BA.
europepmc   +1 more source

Separation and purification of the bovine milk fat globule membrane protein and its effect on improvement of C₂C₁₂mouse skeletal muscle cell proliferation

, 2017
He Li, Weili Xu, Ying Ma, Shaobo Zhou
openalex   +2 more sources

Influenza M2 Proton Channel Activity Selectively Inhibits Trans-Golgi Network Release of Apical Membrane and Secreted Proteins in Polarized Madin-Darby Canine Kidney Cells [PDF]

, 2000
Jennifer R. Henkel, Gregory A. Gibson, Paul A. Poland, Mark Ellis, Rebecca P. Hughey, Ora A. Weisz   +5 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source