Results 31 to 40 of about 9,896,950 (388)
Informing β-cell regeneration strategies using studies of heterogeneity
Molecular Metabolism, 2019 Background: Current therapeutic strategies for type 1 (T1DM) and type 2 diabetes mellitus (T2DM) rely on increasing or substituting endogenous insulin secretion in combination with lifestyle changes.
Daniela Nasteska +3 more
doaj +1 more source
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery
Cell Reports, 2020 Summary: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases.
Carlos M. Guardia +10 more
doaj +1 more source
Circular dichroism spectroscopy of membrane proteins.
Chemical Society Reviews, 2016 Circular dichroism (CD) spectroscopy is a well-established technique for studying the secondary structures, dynamics, folding pathways, and interactions of soluble proteins, and is complementary to the high resolution but generally static structures ...
Andrew J. Miles, Bonnie A. Wallace
semanticscholar +1 more source
Mitochondrial import receptors for precursor proteins [PDF]
, 1991 The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria.
Attardi +34 more
core +1 more source
Nature Communications, 2020 Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 ...
Julia Ast +25 more
doaj +1 more source
Characterization of Translocation Contact Sites Involved in the Import of Mitochondrial Proteins [PDF]
, 1987 Import of proteins into the mitochondrial matrix requires translocation across two membranes. Translocational intermediates of mitochondrial proteins, which span the outer and inner membrane simultaneously and thus suggest that translocation occurs in ...
Herzog, Volker +2 more
core +3 more sources
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Julia Ast +25 more
doaj +1 more source
High-throughput Site-directed Scanning Mutagenesis Using a Two-fragment PCR Approach
Bio-Protocol, 2020 Site-directed scanning mutagenesis is a useful tool applied in studying protein function and designing proteins with new properties, such as increased stability or enzymatic activity. Creating a systematic library of hundreds of site-directed mutants is
Franziska Heydenreich +3 more
doaj +1 more source
High-resolution mass spectrometry of small molecules bound to membrane proteins
Nature Methods, 2016 Small molecules are known to stabilize membrane proteins and to modulate their function and oligomeric state, but such interactions are often hard to precisely define.
J. Gault +16 more
semanticscholar +1 more source
Journal of Fungi, 2021 Multidrug resistance (MDR) transporters belonging to either the ATP-Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) groups are major determinants of clinical drug resistance in fungi.
Atanu Banerjee +5 more
doaj +1 more source