Results 31 to 40 of about 1,639,954 (343)
Frontiers in Endocrinology, 2021 Drugs useful in prevention/treatment of obesity could improve health. Cholecystokinin (CCK) is a key regulator of appetite, working through the type 1 CCK receptor (CCK1R); however, full agonists have not stimulated more weight loss than dieting.
Kaleeckal G. Harikumar +14 more
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Correlated diffusion of membrane proteins and their effect on membrane viscosity [PDF]
, 2008 We extend the Saffman theory of membrane hydrodynamics to account for the correlated motion of membrane proteins, along with the effect of protein concentration on that correlation and on the response of the membrane to stresses. Expressions for the coupling diffusion coefficients of protein pairs and their concentration dependence are derived in the ...
arxiv +1 more source
Membrane proteins and proteomics: Love is possible, but so difficult [PDF]
Electrophoresis 30, S1 (2009) S174-S180, 2009 Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with different proteins, while most protein chemistry methods work mainly, if not only, in water-based ...
arxiv +1 more source
An Introduction to Membrane Proteins
Journal of Proteome Research, 2011 α-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed
Hedin, Linnea E. +2 more
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Structures of membrane proteins [PDF]
Quarterly Reviews of Biophysics, 2010 AbstractIn reviewing the structures of membrane proteins determined up to the end of 2009, we present in words and pictures the most informative examples from each family. We group the structures together according to their function and architecture to provide an overview of the major principles and variations on the most common themes.
Kutti R. Vinothkumar, Richard Henderson
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Frontiers in Pharmacology, 2017 Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags.
Maria Augusta Arruda +11 more
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Structural insight into mitochondrial β-barrel outer membrane protein biogenesis
Nature Communications, 2020 The Sorting and Assembly Machinery (SAM) complex folds beta-barrel proteins and inserts them into the mitochondrial outer membrane. Here authors report cryoEM structures of the SAM complex from Myceliophthora thermophila, which reveals a GST-like fold ...
Kathryn A. Diederichs +8 more
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Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
Frontiers in Molecular Biosciences, 2021 Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones.
Giuseppe Deganutti +7 more
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Thermodynamic competition between membrane protein oligomeric states [PDF]
EPL, 116 (2016), 28005, 2016 Self-assembly of protein monomers into distinct membrane protein oligomers provides a general mechanism for diversity in the molecular architectures, and resulting biological functions, of membrane proteins. We develop a general physical framework describing the thermodynamic competition between different oligomeric states of membrane proteins.
arxiv +1 more source
iScience, 2023 Summary: E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in ...
Lydia Ogrodzinski +7 more
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