Results 61 to 70 of about 1,587,106 (145)
Curvature-sensing and generation by membrane proteins: a review [PDF]
Membrane proteins are crucial in regulating biomembrane shapes and controlling the dynamic changes in membrane morphology during essential cellular processes. These proteins can localize to regions with their preferred curvatures (curvature sensing) and induce localized membrane curvature.
arxiv +1 more source
Regulation of Leukocytes by TspanC8 Tetraspanins and the “Molecular Scissor” ADAM10
Frontiers in Immunology, 2018 A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane protein that functions as a “molecular scissor” to cleave the extracellular regions from its transmembrane target proteins. ADAM10 is well characterized as the ligand-dependent
Alexandra L. Matthews +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2023 Potassium is an essential intracellular ion, and a sufficient intracellular concentration of it is crucial for many processes; therefore it is fundamental for cells to precisely regulate K+ uptake and efflux through the plasma membrane.
Jakub Masaryk +7 more
doaj
Binding and segregation of proteins in membrane adhesion: Theory, modelling, and simulations [PDF]
arXiv, 2019 The adhesion of biomembranes is mediated by the binding of membrane-anchored receptor and ligand proteins. The proteins can only bind if the separation between apposing membranes is sufficiently close to the length of the protein complexes, which leads to an interplay between protein binding and membrane shape. In this article, we review current models
arxiv
A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding
iScience, 2021 Summary: Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion and
Carl W. White +3 more
doaj
A Continuum Poisson-Boltzmann Model for Membrane Channel Proteins [PDF]
arXiv, 2017 Membrane proteins constitute a large portion of the human proteome and perform a variety of important functions as membrane receptors, transport proteins, enzymes, signaling proteins, and more. The computational studies of membrane proteins are usually much more complicated than those of globular proteins.
arxiv
A dark intermediate in the fluorogenic reaction between tetrazine fluorophores and trans-cyclooctene
Biophysical Reports, 2022 Fluorogenic labeling via bioorthogonal tetrazine chemistry has proven to be highly successful in fluorescence microscopy of living cells. To date, trans-cyclooctene (TCO) and bicyclonyne have been found to be the most useful substrates for live-cell ...
Felix Hild +4 more
doaj
Quality control and biophysical characterisation data of VanSA
Data in Brief, 2017 This data article presents the results from quality control experiments including N-terminal sequencing, SEC-MALS and Mass Spectrometry for purified VanSA used in experiments described in (Hughes et al., 2017) [1]; in addition to ligand interaction ...
C.S. Hughes +3 more
doaj +1 more source
Structural basis of THC analog activity at the Cannabinoid 1 receptor
Nature CommunicationsTetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulation and sleep apnea relief.
Thor S. Thorsen +15 more
doaj +1 more source
Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f
Nature CommunicationsThere are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs).
Anastasiia Gusach +14 more
doaj +1 more source