Results 11 to 20 of about 500,253 (300)

Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy

open access: yesActa Pharmaceutica Sinica B
Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses.
Renming Fan   +8 more
doaj   +3 more sources

Differential Packaging Into Outer Membrane Vesicles Upon Oxidative Stress Reveals a General Mechanism for Cargo Selectivity

open access: yesFrontiers in Microbiology, 2021
Selective cargo packaging into bacterial extracellular vesicles has been reported and implicated in many biological processes, however, the mechanism behind the selectivity has remained largely unexplored.
Nichole Orench-Rivera, Meta J. Kuehn
doaj   +1 more source

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts

open access: yesScientific Reports, 2021
Recent studies identified cyclase-associated proteins (CAPs) as important regulators of actin dynamics that control assembly and disassembly of actin filaments (F-actin).
Lara-Jane Kepser   +8 more
doaj   +1 more source

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

open access: yesFrontiers in Cell and Developmental Biology, 2021
Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous “organelles” that have specific functions during the flavivirus life cycle.
Andrea Mikulasova   +6 more
doaj   +1 more source

Membrane remodelling in bacteria [PDF]

open access: yesJournal of Structural Biology, 2016
In bacteria the ability to remodel membrane underpins basic cell processes such as growth, and more sophisticated adaptations like inter-cell crosstalk, organelle specialisation, and pathogenesis. Here, selected examples of membrane remodelling in bacteria are presented and the diverse mechanisms for inducing membrane fission, fusion, and curvature ...
Bohuszewicz, O, Liu, J, Low, HH
openaire   +4 more sources

Lipid droplets are versatile organelles involved in plant development and plant response to environmental changes

open access: yesFrontiers in Plant Science, 2023
Since decades plant lipid droplets (LDs) are described as storage organelles accumulated in seeds to provide energy for seedling growth after germination. Indeed, LDs are the site of accumulation for neutral lipids, predominantly triacylglycerols (TAGs),
Imen Bouchnak   +4 more
doaj   +1 more source

ENTH domain-dependent membrane remodelling

open access: yesSoft Matter, 2021
Cellular membranes are anything but flat structures.
Claudia Steinem, Michael Meinecke
openaire   +4 more sources

Optimizing Gō-MARTINI Coarse-Grained Model for F-BAR Protein on Lipid Membrane

open access: yesFrontiers in Molecular Biosciences, 2021
Coarse-grained (CG) molecular dynamics (MD) simulations allow us to access much larger length and time scales than atomistic MD simulations, providing an attractive alternative to the conventional simulations.
Md. Iqbal Mahmood   +2 more
doaj   +1 more source

Membrane shape remodeling by protein crowding [PDF]

open access: yesBiophysical Journal, 2020
AbstractThe steric repulsion between proteins on biological membranes is one of the most generic mechanisms that cause membrane shape changes. We present a minimal model where a spontaneous curvature is induced by steric repulsion between membrane-associated proteins. Our results show that the interplay between the induced spontaneous curvature and the
Susanne Liese, Andreas Carlson
openaire   +5 more sources

Computational Approaches to Explore Bacterial Toxin Entry into the Host Cell

open access: yesToxins, 2021
Many bacteria secrete toxic protein complexes that modify and disrupt essential processes in the infected cell that can lead to cell death. To conduct their action, these toxins often need to cross the cell membrane and reach a specific substrate inside ...
Weria Pezeshkian   +2 more
doaj   +1 more source

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