In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. [PDF]
, 2018 Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring.
Alnwibit, A. A. +4 more
core +1 more source
Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair [PDF]
, 2010 [Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo.
Blanco García, Francisco J +7 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Role of TGFbRII in myeloid cell mediated regenerative processes and fibroplasia [PDF]
, 2012 Tissue repair and fibrosis are controlled by the interaction of different cell lineages, their soluble factors and matrix signals. Recently, macrophages have been found to be crucial for proper tissue repair.
Ranjan, Rajeev
core
A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing. [PDF]
, 2019 Following injury, skin activates a complex wound healing programme. While cellular and signalling mechanisms of wound repair have been extensively studied, the principles of epidermal-dermal interactions and their effects on wound healing outcomes are ...
Chen, Weitao +7 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Enhancing membrane repair increases regeneration in a sciatic injury model.
PLoS ONE, 2020 Various injuries to the neural tissues can cause irreversible damage to multiple functions of the nervous system ranging from motor control to cognitive function.
Brian J Paleo +7 more
doaj +1 more source
Plasma membrane integrity: implications for health and disease
BMC Biology, 2021 Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment.
Dustin A. Ammendolia +2 more
doaj +1 more source
Membrane dynamics during cellular wound repair
Molecular Biology of the Cell, 2016 Cells rapidly reseal after damage, but how they do so is unknown. It has been hypothesized that resealing occurs due to formation of a patch derived from rapid fusion of intracellular compartments at the wound site. However, patching has never been directly visualized.
Davenport, Nicholas R. +3 more
openaire +2 more sources
Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]
, 2011 Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry +4 more
core +1 more source