Results 101 to 110 of about 483,797 (293)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
ESCRT-Mediated Membrane Repair in Neurodegenerative Disease [PDF]
, 2023 C-terminal truncating mutations in the ESCRT-III protein, CHMP2B have been associated with frontotemporal dementia (FTD). While research has identified autophagic, endolysosomal, and synaptic defects as key underlying neuropathologies, the causative ...
Heffner, Catherine
core
Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains. [PDF]
J Cell BiolThe integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes.
Li YE +10 more
europepmc +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Bacterial control of pores induced by the Type Three Secretion System: Mind the gap
Frontiers in Immunology, 2016 Type Three secretion Systems (T3SSs) are specialized secretion apparatus involved in the virulence of many Gram-negative pathogens, enabling the injection of bacterial type III effectors into host cells. The T3SS-dependent injection of effectors requires
Julie eGuignot +7 more
doaj +1 more source
Defective membrane repair machinery impairs survival of invasive cancer cells
Scientific Reports, 2020 Cancer cells are able to reach distant tissues by migration and invasion processes. Enhanced ability to cope with physical stresses leading to cell membrane damages may offer to cancer cells high survival rate during metastasis.
F. Bouvet +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Mechanisms of Plasma Membrane Repair in Striated Muscle [PDF]
, 2020 Sarcolemma instability is a hallmark of multiple types of muscular dystrophy and is typically caused by two major pathological mechanisms: increased susceptibility of the sarcolemma to contraction-induced damage or decreased capacity to repair the ...
Naylor, Molly
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The antioxidant requirement for plasma membrane repair in skeletal muscle. [PDF]
, 2015 Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently ...
Conrad, M. +7 more
core +1 more source