Organelle-anchored translation factories: the roles of neuronal RNA-binding protein condensates in organizing local protein synthesis in neurological diseases. [PDF]
Protein CellPark S, Lim H, Lee JA.
europepmc +1 more source
AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma
Medicinal Research Reviews, EarlyView.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo +4 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting
Medicinal Research Reviews, EarlyView.ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama +2 more
wiley +1 more source
Nim1-related kinases regulate septin organization and cytokinesis by modulating Hof1 at the cell division site. [PDF]
ElifeBhojappa B +7 more
europepmc +1 more source
Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis
PROTEOMICS, EarlyView.ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima +6 more
wiley +1 more source
Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes. [PDF]
CellsNiinuma SA +4 more
europepmc +1 more source
Conjugated Polymers Engineered for Flexible/Stretchable Electronics
Journal of Polymer Science, EarlyView.This review highlights glass transition temperature (Tg) as the central parameter linking molecular structure to device performance in conjugated polymers. By tuning backbone rigidity, side‐chain architecture, and dynamic bonding, Tg governs the balance between π–π stacking–enabled charge transport and mechanical compliance.
Yunchong Yang +5 more
wiley +1 more source
Genome-Wide Identification and Characterization of the <i>MAG2</i> Gene Family in <i>Medicago sativa</i>. [PDF]
Genes (Basel)Xu C +8 more
europepmc +1 more source
Sodium Ions Affect GPR17 Conformational States and Functionality
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo +6 more
wiley +1 more source