Results 71 to 80 of about 47,795 (200)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Mitochondria-Plasma Membrane Contact Sites: Emerging Regulators of Mitochondrial Form and Function

Contact
Sites of close apposition between organelles, known as membrane contact sites (MCSs), are critical regulators of organelle function. Mitochondria form elaborate reticular networks that perform essential metabolic and signaling functions.
Jason C Casler, Matilde V Neto, Thomas Burgoyne, Laura L Lackner   +3 more
doaj   +1 more source

Protocol for studying membrane protein dynamics and associated synaptic vesicle recruitment on native membrane sheets

STAR Protocols
Summary: Plasma membrane sheets provide direct access to the cytosolic face of the cellular membrane while retaining membrane-associated proteins and lipids.
Akshay Kapadia, Anne-Sophie Hafner
doaj   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Scalable Multilayer PTFE‐Reinforced Membranes for Durable, High‐Current‐Density Hydroxide Exchange Membrane Water Electrolysis in Dilute Alkali

Advanced Science, EarlyView.
Low‐Tg HEMs are designed to improve membrane‐electrode adhesion by promoting intimate contact with catalyst layers. After hydration, the membrane develops a hydrogel‐like network that supports water uptake and ion transport while retaining mechanical robustness.
Zhiwei Ren, Yun Zhao, Rui Zhang, Tao Wei, Yingran Zhu, Yangkai Han, Tongzhou Li, Haitao Zhang, Zhigang Shao   +8 more
wiley   +1 more source

Membrane Tethering of SepF, a Membrane Anchor for the Mycobacterium tuberculosis Z-ring. [PDF]

J Mol Biol, 2022
Dey S, Zhou HX.
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy. [PDF]

Cell Rep, 2022
Hawkins WD, Leary KA, Andhare D, Popelka H, Klionsky DJ, Ragusa MJ.   +5 more
europepmc   +1 more source