Results 241 to 250 of about 534,194 (307)

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

A subset of type 4 secretion system effectors of <i>Brucella</i> spp. associates to outer membrane vesicles. [PDF]

Microlife
Ketterer M, Ganief N, Chiquet P, Lannoy A, Verhaeghe A, Braunweiler J, Dieu M, De Bolle X, Québatte M, Dehio C.   +9 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Membrane Vesicles from <i>Lactobacillus acidophilus</i> Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages. [PDF]

Int J Mol Sci
Lonngi Sosa CD, González Díaz FR, Álvarez HR, Vargas Ruiz A, Higuera Piedrahita RI, de la Cruz Cruz HA, Cuéllar Ordaz JA, Ramírez-Rico G, Negrete Abascal E, Reyes López M, González Ruíz C.   +10 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Lactiplantibacillus plantarum Membrane Vesicles (MVs) exhibit immunomodulatory and bactericidal effects against Escherichia coli and Salmonella Typhimurium. [PDF]

PLoS One
Lonngi Sosa CD, González Díaz FR, Ramírez Álvarez H, Vargas Ruíz A, Muciño Hernández JL, Higuera Piedrahita RI, de la Cruz Cruz HA, Leal Hernández M, Ramírez-Rico G, Cuéllar Ordaz JA, González Ruíz C.   +10 more
europepmc   +1 more source

Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter. [PDF]

J Extracell Vesicles
Zhao M, He M, Lin X, Wu K, Yang F, Chen X, Li H, Wang H, Tang Y.   +8 more
europepmc   +1 more source

Proteomic alterations in outer membrane vesicles of carbapenem-resistant <i>Klebsiella pneumoniae</i> isolated from sepsis patients. [PDF]

Open Med (Wars)
Kang J, Xu L, Xiao T.
europepmc   +1 more source