Results 141 to 150 of about 105,016 (295)

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Membranous Nephropathy after Subcutaneous Mercury Injection

INTRODUCTION: Subcutaneous elemental mercury injection is typically not associated with systemic toxicity. This case report describes a man who developed persistent membranous nephropathy temporally associated with intentional subcutaneous elemental ...
Johnson-Arbor, Kelly, Taha, Sammy
core   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

Different Dosage Regimens of Rituximab in Primary Membranous Nephropathy Treatment: A Systematic Review [PDF]

Yi Yu,1 Ricong Xu,1 Zhijian Li,2,3 Qijun Wan1 1Department of Nephrology, The First Affiliated Hospital of Shenzhen University, The Second People’s Hospital of Shenzhen, Shenzhen, 518039, People’s Republic of China; 2Department of Nephrology, The First ...
Wan Q, Li Z, Xu R, Yu Y
core  

Pathogenesis and Treatment of Membranous Nephropathy

Kidney International, 1979
A 19-year-old woman was admitted to New England Medical Center Hospital (NEMCH) for evaluation of the nephrotic syndrome. The patient was in excellent health until proteinuria was first detected 10 months earlier during the third month of her first pregnancy.
openaire   +2 more sources

Real‐world observational study evaluating metabolic and kidney outcomes in patients living with chronic kidney disease and type 2 diabetes mellitus with obesity prescribed tirzepatide

Diabetic Medicine, EarlyView.
Abstract Background Obesity and type 2 diabetes mellitus (T2DM) accelerate chronic kidney disease (CKD) progression. Tirzepatide, a dual glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist, has demonstrated metabolic and potential renoprotective benefits in clinical trials.
Jack E. Carruthers, Xi Yan Ooi, Dawn Goodall, Jo Reed, Rachna Bedi, Adrian McGrath, Michelle Willicombe, Parizad Avari, Andrew H. Frankel   +8 more
wiley   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Surface charge alterations in urinary extracellular vesicles mirror diabetic kidney disease pathophysiology

The FEBS Journal, EarlyView.
This study reveals that changes in the electrical charge, that is zeta potential of large extracellular vesicles (uEVs) found in urine, can reflect disease progression from diabetes to kidney scarring (fibrosis). With further clinical development, measurement of uEVs charge could provide a simple, noninvasive way to monitor disease progression and help
Melanie Tepuš, Maria Pia Savoca, Mabrouka Maamra, Conor J. Meehan, Dimitrios S. Goumenos, Timothy Johnson, Elisabetta A. M. Verderio   +6 more
wiley   +1 more source

The role of TOMM20 in Mediating TERT translocation to mitochondria and its impact on mitophagy in membranous nephropathy

BMC Nephrology
Background In idiopathic membranous nephropathy (MN)—now a leading glomerular cause of end-stage kidney disease—mitochondrial quality control via mitophagy is increasingly recognized as a determinant of podocyte fate, yet the molecular switches governing
Limiao Yang, Hongle Yang, Mingming Zhang, Feifei Zhang, Xiaomei Liu, Zhiping Zhang, Jing Wang, Xiaolu Chen, Yuexuan Wang, Rui Zhang, Weihao Li   +10 more
doaj   +1 more source