Results 151 to 160 of about 105,016 (295)
The FEBS Journal, EarlyView.Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal +18 more
wiley +1 more source
HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise
HIV Medicine, EarlyView.Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil +4 more
wiley +1 more source
, 2001 Membranous nephropathy and anti-neutrophil cytoplasmic antibody-associated glomerulonephritis: a report of 2 ...
PA Hill (14541284) +3 more
core
Characterization of novel antigens in membranous nephropathy [PDF]
, 2016 INTRODUCTION: Membranous nephropathy is an autoimmune disease that targets glomeruli of the kidney. Previous discoveries in membranous nephropathy include the discovery of megalin as an antigen in the proximal tubular brush border fraction (Fx1A) and ...
Coles, Paige
core
Unmasking the Influence of Viral Micro‐RNAs on Host Immunity
Immunology &Cell Biology, EarlyView.Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton +1 more
wiley +1 more source
Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, EarlyView.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley +1 more source
Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis
Journal of Clinical Periodontology, EarlyView.ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali +5 more
wiley +1 more source
Membranous Nephropathy Associated with Eosinophilic Gastroenteritis: First Report [PDF]
, 2014 Membranous nephropathy represents the most common cause of nephrotic syndrome in adult patients. In 85% of cases the disease is classified as idiopathic membranous nephropathy, and in the remainder 15 % as secondary membranous nephropathy (systemic lupus
Giovanni Manca Rizza +7 more
core
Close relationship between β2‐microglobulin and type 2 diabetes‐associated peripheral neuropathy
Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims/Introduction This study aimed to elucidate the correlation between β2‐microglobulin (β2‐MG) and peripheral neuropathy in type 2 diabetes mellitus (T2DM). Materials and Methods Diabetic peripheral neuropathy (DPN) was defined on the nerve conduction study (NCS).
Jingfang Shao +3 more
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li +6 more
wiley +1 more source