Results 51 to 60 of about 105,016 (295)

Diagnosis and course of membranous nephropathy in adults: comparison by age group

Kidney & Blood Pressure Research, 2022
Introduction There have been few studies comparing younger and older adults with membranous nephropathy. The objective of this study was to compare younger and older patients with membranous nephropathy, in terms of the clinical, etiological, remission ...
Renata Paula Martins Brandão Paulo, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias   +4 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Membranous Nephropathy in the Dog [PDF]

Veterinary Pathology, 1986
Membranous nephropathy, a disease syndrome characterized by severe proteinuria and often accompanied by the nephrotic syndrome, was identified in 29% of a population of 46 proteinuric dogs. Renal lesions were characterized by the presence of subepithelial immunoglobulin deposits distributed diffusely along the glomerular capillary wall. Advanced stages
R S, Jaenke, T A, Allen
openaire   +2 more sources

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Fulminant cerebral infarctions with membranous nephropathy.

, 1993
Arterial thromboses, including cerebral infarction, are a rare complication of the nephrotic syndrome. A 37-year-old woman presented with right upper extremity ischemia, left middle cerebral artery thrombosis, and right cerebellar infarction ...
S Chaturvedi, Chaturvedi, S
core   +1 more source

Membranous Nephropathy with Crescents [PDF]

Journal of the American Society of Nephrology, 2011
Membranous nephropathy is a common cause of nephrotic syndrome in adults and can be primary or secondary to systemic lupus erythematosus, chronic infection, or drugs. Rapid decline in renal function in patients with membranous nephropathy may be due to renal vein thrombosis, malignant hypertension, or an additional superimposed destructive process ...
Amanda Walton, Basford, Julia, Lewis, Jamie P, Dwyer, Agnes B, Fogo   +3 more
openaire   +2 more sources

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

A rare case of membranous nephropathy associated with chronic inflammatory demyelinating polyradiculoneuropathy

, 2023
A rare case of membranous nephropathy associated with chronic inflammatory demyelinating ...
Minghui Zhao (558468), Ying Tan (346135), Fude Zhou (16022821), Qiong Zhang (172309), Lingchao Meng (8339823), Rong Xu (296325)   +5 more
core   +1 more source

Membranous nephropathy in the UK Biobank

PLOS ONE, 2023
Background Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare disease. Making use of the UK Biobank, a unique resource holding a clinical dataset and stored DNA, serum and urine for ~500,000 participants, this study ...
Patrick Hamilton, Kieran Blaikie, Stephen A. Roberts, Matthew Gittins, Mallory L. Downie, Sanjana Gupta, Catalin Voinescu, Durga Kanigicherla, Horia Stanescu, Robert Kleta, Paul Brenchley   +10 more
openaire   +5 more sources

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source