Results 41 to 50 of about 25,753 (298)

Recent progress in the pathogenesis of membranous nephropathy

Linchuang shenzangbing zazhi, 2022
Membranous nephropathy （MN） is a kind of autoimmune disease caused by forming immune complex of antigen and antibody in glomerulus.A definite diagnosis is dependent upon renal biopsy and serological PLA2R1 test.And serological test is vital for further ...
He Zhi-hua, Wang Li-hua
doaj  

TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy [PDF]

, 2014
Background: Activating mutations in the Transient Receptor Potential channel C6 (TRPC6) cause autosomal dominant focal segmental glomerular sclerosis (FSGS).
Berden, J.H.M. (Jo H.), Coenen, M.J. (Marieke), Hoefsloot, E.H. (Lies), Hofstra, J.M. (Julia), Knoers, N.V.A.M. (Nine), Nijenhuis, T. (Tom), Schijvenaars, M.M.V.A.P. (Mascha), Vlag, J. (Johan) van der, Wetzels, J.F.M. (Jack)   +8 more
core   +1 more source

Case Report: Membranous Nephropathy Secondary to Cobalamin C Disease

Frontiers in Medicine, 2022
BackgroundMutation of MMACHC causes inherited cobalamin C disease with methylmalonic academia (MMA) and homocysteinemia. Renal complications may also be present in patients with this deficiency.
Qiang Wang, Qi Wang, Yanxia Gao, Chenquan Tang, Zhaoli Gao, Zhao Hu   +5 more
doaj   +1 more source

Designing Clinical Trials for the Treatment of Membranous Nephropathy in the Anti-Phospholipase A2 Receptor 1 Era: Results of a NephCure Membranous Nephropathy Workshop

Glomerular Diseases
Primary membranous nephropathy is a common cause of adult-onset nephrotic syndrome, with an overall incidence of 12 cases per million per year.
Marco Prunotto, Patrick H. Nachman, Barbara S. Gillespie, Laurence H. Beck, Aliza M. Thompson, Austin H. Hu, Elizabeth A. Stafford, Josh M. Tarnoff, Brad H. Rovin   +8 more
doaj   +1 more source

Diagnosis and course of membranous nephropathy in adults: comparison by age group

Kidney & Blood Pressure Research, 2022
Introduction There have been few studies comparing younger and older adults with membranous nephropathy. The objective of this study was to compare younger and older patients with membranous nephropathy, in terms of the clinical, etiological, remission ...
Renata Paula Martins Brandão Paulo, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias   +4 more
doaj   +1 more source

Acute kidney injury and post-reperfusion syndrome in liver transplantation [PDF]

, 2016
In the past decades liver transplantation (LT) has become the treatment of choice for patients with end stage liver disease (ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors
Evison, Felicity, Ferguson, James, Gunson, Bridget, Mitterhofer, Anna Paola, Muiesan, Paolo, Scalera, Irene, Sharif, Adnan, Tinti, Francesca, Umbro, Ilaria   +8 more
core   +3 more sources

Current research status of PLA2R and malignancy associated membranous nephropathy

Linchuang shenzangbing zazhi, 2021
As a common cause of nephropathy syndrome in adults, membranous nephropathy（MN）often leads to end-stage renal disease.PLA2R related testing may aid a definite diagnosis of idiopathic MN.In recent years, we have detected some patients of malignancy ...
Zhu Wan-ting, Wang Yan-qiu
doaj  

Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy

Frontiers in Immunology, 2018
Membranous nephropathy is an immune kidney disease caused by IgG antibodies that form glomerular subepithelial immune complexes. Proteinuria is mediated by complement activation, as a result of podocyte injury by C5b-9, but the role of specific ...
Wentian Luo, Wentian Luo, Florina Olaru, Florina Olaru, Jeffrey H. Miner, Laurence H. Beck, Johan van der Vlag, Joshua M. Thurman, Dorin-Bogdan Borza, Dorin-Bogdan Borza   +9 more
doaj   +1 more source

A case of myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated glomerulonephritis and concurrent membranous nephropathy [PDF]

, 2013
BACKGROUND: Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) and concurrent membranous nephropathy (MN) are very rare combination. Their causal relationship has been suggested, but not determined.
Hideaki Yamabe, Hiroshi Osawa, Ikuyo Narita, Ken Okumura, Michiko Shimada, Norio Nakamura, Reiichi Murakami, Takeshi Fujita, Yuko Shimaya   +8 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source