Results 51 to 60 of about 945,021 (335)

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

Neurobiology of Disease, 2010
Previously we showed that anti-Aβ peptide immunotherapy significantly attenuated Alzheimer's-like amyloid deposition in the central nervous system of aged canines.
Vitaly Vasilevko, Viorela Pop, Hyun Jin Kim, Tommy Saing, Charles C. Glabe, Saskia Milton, Edward G. Barrett, Carl W. Cotman, David H. Cribbs, Elizabeth Head   +9 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

Neurobiology of Disease, 2013
Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.
Karlie A. Intlekofer, Carl W. Cotman
doaj   +1 more source

Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial

Frontiers in Medicine, 2020
Reluctance to undergo lumbar puncture (LP) is a barrier to neurological disease biomarker research. We assessed whether an educational intervention increased willingness to consider research LP and whether message framing modified intervention ...
Megan G. Witbracht, Olivia M. Bernstein, Vanessa Lin, Christian R. Salazar, S. Ahmad Sajjadi, S. Ahmad Sajjadi, Dan Hoang, Chelsea G. Cox, Daniel L. Gillen, Daniel L. Gillen, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill   +13 more
doaj   +1 more source

Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults

Frontiers in Aging Neuroscience, 2022
ObjectiveValidation and widespread use of markers indicating decline in serial neuropsychological exams has remained elusive despite potential value in prognostic and treatment decision-making.
Jean K. Ho, Daniel A. Nation, Daniel A. Nation   +2 more
doaj   +1 more source

Declarative Memory Impairment and Emotional Bias in Recurrent Depression with a Seasonal Pattern: The Interplay between Emotion and Cognition in Seasonal Affective Disorder [PDF]

, 2022
Carla Iorio, Francesca Pacitti, Alessandro Rossi, Paola Iorio, Assunta Pompili   +4 more
openalex   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

The effect of a training programme stimulating language functions on Alzheimer-type dementia and maintenance of language skills

Aktualności Neurologiczne, 2017
In dementia of the Alzheimer’s type, memory and language impairments coexist, occur early and aggravate with time. The aim of this study was to assess the effect of our proprietary language function stimulating programme on cognitive functions and the ...
Andrzej Potemkowski, Marta Wąsik, Marcin Ratajczak   +2 more
doaj   +1 more source

Musiikki muistisairaan vanhuksen hyvinvoinnin edistäjänä : Hoitonetti [PDF]

, 2013
Iäkkäämpien ikäryhmien osuuden kasvaessa myös muistisairauksia sairastavien määrä moninkertaistuu. Muistisairaudet ovat isoin riskitekijä, joka johtaa iäkkään ihmisen pois kodistaan ympärivuorokautiseen hoitopaikkaan.
Haapamäki, Tiina
core  

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source