Results 51 to 60 of about 947,925 (355)

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

Neurobiology of Disease, 2013
Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.
Karlie A. Intlekofer, Carl W. Cotman
doaj   +1 more source

Education and Message Framing Increase Willingness to Undergo Research Lumbar Puncture: A Randomized Controlled Trial

Frontiers in Medicine, 2020
Reluctance to undergo lumbar puncture (LP) is a barrier to neurological disease biomarker research. We assessed whether an educational intervention increased willingness to consider research LP and whether message framing modified intervention ...
Megan G. Witbracht, Olivia M. Bernstein, Vanessa Lin, Christian R. Salazar, S. Ahmad Sajjadi, S. Ahmad Sajjadi, Dan Hoang, Chelsea G. Cox, Daniel L. Gillen, Daniel L. Gillen, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill, Joshua D. Grill   +13 more
doaj   +1 more source

Neuropsychological Decline Stratifies Dementia Risk in Cognitively Unimpaired and Impaired Older Adults

Frontiers in Aging Neuroscience, 2022
ObjectiveValidation and widespread use of markers indicating decline in serial neuropsychological exams has remained elusive despite potential value in prognostic and treatment decision-making.
Jean K. Ho, Daniel A. Nation, Daniel A. Nation   +2 more
doaj   +1 more source

Electrical Stimulation Modulates High γ Activity and Human Memory Performance. [PDF]

, 2018
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition.
Berry, Brent M., Davis, Kathryn A., Ezzyat, Youssef, Gorniak, MD, Richard, Gross, Robert E., Jobst, Barbara C., Kahana, Michael J., Khadjevand, Fatemeh, Kremen, Vaclav, Kucewicz, Michal T., Lega, Bradley, Miller, Laura R., Rizzuto, Daniel S., Sperling, Michael R., Stead, S Matt, Stein, Joel M., Wanda, Paul, Worrell, Gregory A,   +17 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

Neurobiology of Disease, 2014
Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression.
David Baglietto-Vargas, Masashi Kitazawa, Elaine J. Le, Tatiana Estrada-Hernandez, Carlos J. Rodriguez-Ortiz, Rodrigo Medeiros, Kim N. Green, Frank M. LaFerla   +7 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Effectiveness of a local recruitment registry in older adults in Southern California

BMC Medical Research Methodology
Background Despite their potential as tools for improving the efficiency of accrual in clinical research, few analyses have assessed the effectiveness of recruitment registries.
Adam I. Birnbaum, Adrijana Gombosev, Zion T. Grant-Freeman, Dan Hoang, Daniel L. Gillen, Joshua D. Grill   +5 more
doaj   +1 more source