Results 11 to 20 of about 3,490 (181)

Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma [PDF]

BMC Cancer, 2006
Background Germline mutations in RET are responsible for multiple endocrine neoplasia type 2 (MEN2), an autosomal dominantly inherited cancer syndrome that is characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid ...
Pacak Karel, Zhuang Zhengping, Libutti Steven K, Tannapfel Andrea, Vortmeyer Alexander O, Brouwers Frederieke M, Koch Christian A, Neumann Hartmut PH, Paschke Ralf   +8 more
doaj   +7 more sources

Novel targeted therapeutics for MEN2 [PDF]

Endocrine-Related Cancer, 2018
The rearranged during transfection ( RET ) proto-oncogene was recognized as the multiple endocrine neoplasia type 2 (MEN2) causing gene in 1993. Since then, much effort has been put into a clear understanding of its oncogenic signaling, its biochemical function and ways to block its aberrant ...
Redaelli, Sara, Plaza-Menacho, Ivan, Mologni, Luca   +2 more
openaire   +3 more sources

Functional analysis of RET in MEN2 [PDF]

, 2006
De erfelijke kankersyndromen Multipele Endocrine Neoplasieën (MEN2A en 2B) en het verwante syndroom familiaire medullaire schildklierkanker (FMTC; de ziekte van Hirschsprung), worden veroorzaakt door mutaties in het RET-gen. Het promotieonderzoek van Ivan Plaza Menacho was erop gericht de mutante RET eiwitten, zoals die voorkomen bij patiënten met MEN2/
Plaza-Menacho, Ivan
core   +24 more sources

Impact of gastrointestinal symptoms on quality of life in MEN2 [PDF]

Clinical Endocrinology, 2020
AbstractContextBesides medullary thyroid carcinoma and other endocrinopathies, people with Multiple Endocrine Neoplasia Type 2 (MEN2) are at risk of gastrointestinal (GI) symptoms.ObjectiveTo investigate the impact of GI symptoms on the daily lives of patients with MEN2.DesignAn online survey was conducted among patients with MEN2 via the Association ...
Mariia Goncharova, Joanna Grey, Maralyn Druce   +2 more
openaire   +4 more sources

Psychosocial Characteristics and Experiences in Patients with Multiple Endocrine Neoplasia Type 2 (MEN2) and Medullary Thyroid Carcinoma (MTC)

Children, 2022
Multiple Endocrine Neoplasia type 2 (MEN2) is a genetic cancer syndrome for which there are limited data pertaining to the quality of life and psychosocial experiences of persons affected.
Robin Lockridge, Sima Bedoya, Taryn Allen, Brigitte C. Widemann, Srivandana Akshintala, John Glod, Lori Wiener   +6 more
doaj   +2 more sources

Multiple endocrine neoplasia type 2 (MEN2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on Multiple endocrine neoplasia type 2 (MEN2), with data on clinics, and the genes involved.
Giraud, S
openaire   +3 more sources

The penetrance of MEN2 pheochromocytoma is not only determined by RET mutations [PDF]

Endocrine-Related Cancer, 2017
Multiple endocrine neoplasia type 2 (MEN2) is a rare syndrome subdivided into 2 main entities: MEN2A and MEN2B (Donis-Keller et al. 1993, Mulligan et al. 1993, Eng et al. 1996). Genetic results can predict the natural history of medullary thyroid carcinoma (MTC) depending on the mutation of RET.
Castinetti, Frederic, Maia, Ana Luiza, Peczkowska, Mariola, Barontini, Marta, Hasse-Lazar, Kornelia, Links, Thera P, Toledo, Rodrigo A, Dvorakova, Sarka, Mian, Caterina, Bugalho, Maria Joao, Zovato, Stefania, Alevizaki, Maria, Kvachenyuk, Andrei, Bausch, Birke, Loli, Paola, Bergmann, Simona R, Patocs, Attila, Pfeifer, Marija, Costa, Josefina Biarnes, von Dobschuetz, Ernst, Letizia, Claudio, Valk, Gerlof, Barczynski, Marcin, Czetwertynska, Malgorzata, Plukker, John T M, Sartorato, Paola, Zelinka, Tomas, Vlcek, Petr, Yaremchuk, Svetlana, Weryha, Georges, Canu, Letizia, Wohllk, Nelson, Sebag, Frederic, Walz, Martin K, Eng, Charis, Neumann, Hartmut P H   +35 more
core   +16 more sources

Role of RET genetic variants in MEN2-associated pheochromocytoma [PDF]

European Journal of Endocrinology, 2014
Background: RET polymorphisms have been involved in the clinical presentation and prognosis of multiple endocrine neoplasia type 2 (MEN2)-associated medullary thyroid carcinoma.ObjectiveTo investigate the effect of RET variants on the penetrance of pheochromocytoma (PHEO) in MEN2 patients.
Siqueira, Débora Rodrigues, Ceolin, Lucieli, Ferreira, Carla Vaz, Romitti, Mirian, Maia, Silvana Cavalcante, Maciel, Léa Maria Zanini LM, Maia, Ana Luiza   +6 more
openaire   +4 more sources

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study [PDF]

Endocrine Connections, 2019
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated
Rui M B Maciel, Cleber P Camacho, Lígia V M Assumpção, Natassia E Bufalo, André L Carvalho, Gisah A de Carvalho, Luciana A Castroneves, Francisco M de Castro Jr, Lucieli Ceolin, Janete M Cerutti, Rossana Corbo, Tânia M B L Ferraz, Carla V Ferreira, M Inez C França, Henrique C R Galvão, Fausto Germano-Neto, Hans Graf, Alexander A L Jorge, Ilda S Kunii, Márcio W Lauria, Vera L G Leal, Susan C Lindsey, Delmar M Lourenço Jr, Léa M Z Maciel, Patrícia K R Magalhães, João R M Martins, M Cecília Martins-Costa, Gláucia M F S Mazeto, Anelise I Impellizzeri, Célia R Nogueira, Edenir I Palmero, Cencita H C N Pessoa, Bibiana Prada, Débora R Siqueira, Maria Sharmila A Sousa, Rodrigo A Toledo, Flávia O F Valente, Fernanda Vaisman, Laura S Ward, Shana S Weber, Rita V Weiss, Ji H Yang, Magnus R Dias-da-Silva, Ana O Hoff, Sergio P A Toledo, Ana L Maia   +45 more
doaj   +7 more sources

MEN2: surgical precision in the era of precision medicine. [PDF]

Endocr Relat Cancer
Graphical abstract Abstract Medullary thyroid cancer, phaeochromocytoma and primary hyperparathyroidism in patients with multiple endocrine neoplasia type 2 can all be cured by surgery on the condition that they are detected early ...
Kurzawinski TR, Butler CR, Aziz TA.
europepmc   +6 more sources