Results 21 to 30 of about 3,490 (181)
A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion [PDF]
Case Reports in Endocrinology, 2020 Background. Multiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by RET proto-oncogene mutation. Two different clinical variants of MEN2 are known (MEN2A and MEN2B): medullary thyroid carcinoma (MTC) almost always present and
Carlotta Giani +16 more
doaj +3 more sources
Medullary thyroid cancer in MEN2 pediatric/adolescent carriers of RET mutation: genotype/phenotype correlation and outcome in a retrospective series of 23 patients [PDF]
Frontiers in OncologyBackgroundMultiple endocrine neoplasia type 2 syndrome (MEN2) is a hereditary disease resulting from mutations of the rearranged during transfection (RET) protooncogene subclassified into MEN2A [medullary thyroid carcinoma (MTC), pheochromocytoma, and ...
Guenda Di Benedetto +10 more
doaj +2 more sources
Functional and genetic studies in MEN2 and Hirschsprung disease [PDF]
, 2010 Hirschsprung disease (HSCR) and Multiple Endocrine Neoplasia type 2 (MEN2) are two seemingly unrelated neural crest-associated disorders that can be caused by germline mutations in RET.
Moreira Alves, Maria Manuela +1 more
openaire +4 more sources
Clinical features and signaling effects of RET D631Y variant multiple endocrine neoplasia type 2 (MEN2) [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims Germline mutations of the rearranged during transfection (RET) gene cause multiple endocrine neoplasia type 2 (MEN2). About 85% of RET mutations in MEN2 occur in codon Cys634.
Ji-young Lee +7 more
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Molecular biology of the MEN2 gene [PDF]
Journal of Internal Medicine, 1998 Santoro M, Melillo RM, Carlomagno F, Visconti R, De Vita G, Salvatore G, Lupoli G, Fusco A, Vecchio G (Università di Napoli, Naples, Italy). Molecular biology of the MEN2 gene (Minisymposium: MEN & VHL). J Intern Med 1998; 243: 505–8.Cancer is a genetic disease caused by ‘gain of function’ mutations of oncogenes and ‘loss of function’ mutations of ...
SANTORO M +8 more
openaire +6 more sources
Frontiers in Endocrinology, 2020 Multiple endocrine neoplasia type 2 (MEN2) is a neuroendocrine cancer syndrome characterized by medullary thyroid carcinoma, in combination or not with pheochromocytoma, hyperparathyroidism, and extra-endocrine features.
Shu-Yuan Li +5 more
doaj +1 more source
Multiple endocrine neoplasia 2: an overview
Therapeutic Advances in Chronic Disease, 2022 This review article discusses the diagnosis and treatment of patients with multiple endocrine neoplasia type 2 (MEN2). The most common tumors associated with MEN2 are those of the parathyroid, thyroid, and adrenal glands.
B Saravana-Bawan, JD Pasternak
doaj +1 more source
MEN2 phenotype in a family with germline heterozygous rare RET K666N variant
Endocrinology, Diabetes & Metabolism Case ReportsMultiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by germline-activating pathogenic variants in the RET proto-oncogene.
A La Greca +8 more
doaj +3 more sources
Endocrines, 2022 Multiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence of two or more endocrine gland tumors in a patient or related individuals in the same family.
Marianne Jacob +3 more
doaj +1 more source
Interdisciplinary data bank in oncoendocrinology. Medullary thyroid cancer and type 2 multiple endocrine neoplasia syndromes [PDF]
Эндокринная хирургия, 2020 Medullary thyroid cancer (MTC) is about 5% of all thyroid carcinomas and is hereditary in 2030% of cases. Multiple endocrine neoplasia syndrome type 2 (MEN2), in addition to medullary thyroid cancer, may include pheochromocytoma, hyperparathyroidism, and
Pavel O. Rumiantsev +5 more
doaj +1 more source