Results 131 to 140 of about 271,662 (318)

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Exploring the Link Between Psoriasis and Genetic Predictors of Cardiac Magnetic Resonance Traits: A Bidirectional Mendelian Randomization Study

iNew Medicine, EarlyView.
ABSTRACT Psoriasis is a chronic autoimmune disease characterized by systemic inflammation and skin involvement, affecting millions of individuals worldwide. However, few studies have evaluated whether psoriasis and cardiac magnetic resonance imaging (CMR) traits share a common genetic basis.
Junlin Yang, Pengzhan Yin, Shutian An, Zhanglei Li, Yewen Jiang, Jun Wang, Yongqiang Yu, Ren Zhao, Xiaohu Li   +8 more
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Interconnections between urolithiasis and oral health: a cross-sectional and bidirectional Mendelian randomization study [PDF]

, 2023
Jin‐Zhou Xu, Jian‐Xuan Sun, Lin-Tao Miao, Si-Han Zhang, Wenjie Wang, Chen‐Qian Liu, Qi‐Dong Xia, Junlin Lu, Peng Zhou, Yongman Lv, Yang Xun, Wei Guan, Lei Cui   +12 more
openalex   +1 more source

Dose‐dependent association of systemic comorbidities with periodontitis severity: A large population cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley   +1 more source

Identifying potential therapeutic targets in lung adenocarcinoma: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization [PDF]

Youpeng Chen, Enzhong Li, Zhenglin Chang, Tingting Zhang, Zhenfeng Song, Haojie Wu, Zhangkai J. Cheng, Baoqing Sun   +7 more
openalex   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank [PDF]

Tingjing Zhang, Yu An, Zhenfei Shen, Honghao Yang, Jinguo Jiang, Liangkai Chen, Yanhui Lu, Yang Xia   +7 more
openalex   +1 more source

The causal role between circulating immune cells and diabetic nephropathy: a bidirectional Mendelian randomization with mediating insights [PDF]

Ning Shen, Shangwei Lu, Zhijuan Kong, Ying Gao, Jinxiu Hu, Shuxuan Si, Junlin Wang, Jie Li, Wei Han, Rong Wang, Zhimei Lv   +10 more
openalex   +1 more source