Results 11 to 20 of about 236,698 (345)

Mendelian and Non-Mendelian Quadratic Operators [PDF]

open access: yesarXiv, 2013
In this paper, we attempt to provide mathematical models of Mendelian and Non-Mendelian inheritances of the bisexual population system having Fisher's {\textbf{1:1}} principle. In our model, we always assume that distributions of the same phenotype of female and male populations are equal. We study the evolution of a Mendelian trait.
Mansoor Saburov   +2 more
arxiv   +5 more sources

Celer: an Efficient Program for Genotype Elimination [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2010
This paper presents an efficient program for checking Mendelian consistency in a pedigree. Since pedigrees may contain incomplete and/or erroneous information, geneticists need to pre-process them before performing linkage analysis.
Nicoletta De Francesco   +2 more
doaj   +2 more sources

The Interpretation of Mendelian Phenomena [PDF]

open access: bronzeNature, 1907
APROPOS of the discussion on the interpretation of Mendelian phenomena, may I seek enlightenment on one or two points from your readers? Mendelian phenomena are possible only when reproduction is bi-parental. They cannot occur, of course, when it is parthenogenetic.
G. ARCHDALL REID
  +9 more sources

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

open access: yes, 2013
We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified ...
A Hodgkinson   +29 more
arxiv   +6 more sources

Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis. [PDF]

open access: yesJ Int Med Res
Objective Observational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.
Zhou S   +5 more
europepmc   +2 more sources

Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study. [PDF]

open access: yesSAGE Open Med
Objective: Previous observational studies reported that ankylosing spondylitis is closely related to hypertension. However, it is still controversial whether the association between ankylosing spondylitis and hypertension is causal.
Hu W, Zhang K, Yang G, Wang H, Gao Y.
europepmc   +2 more sources

Mendelian randomization

open access: yesNature Reviews Methods Primers, 2022
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson   +10 more
openaire   +4 more sources

Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis

open access: yesFrontiers in Genetics, 2022
Purpose: Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors.
Peng Shu   +4 more
doaj   +1 more source

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