Results 11 to 20 of about 271,662 (318)

EVOLUTION IN MENDELIAN POPULATIONS [PDF]

Bulletin of Mathematical Biology, 1931
The frequency of a given gene in a population may be modified by a number of conditions including recurrent mutation to and from it, migration, selection of various sorts and, far from least in importance, were chance ...
Sewall Wright
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Mendelian randomization

Nature Reviews Methods Primers, 2022
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson, M. Maria Glymour, Michael V. Holmes, Hyunseung Kang, Jean Morrison, Marcus R. Munafò, Tom Palmer, C. Mary Schooling, Chris Wallace, Qingyuan Zhao, George Davey Smith   +10 more
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Mendelian explorations

Journal of Organization Design, 2023
AbstractIn his most recent book, Daniel Levinthal develops a theory of strategy and organization centred around a “Mendelian executive” who consciously seeks new strategic opportunities but is constrained by path dependence to search in spaces adjacent to the current state of affairs.
Marengo, L, Settepanella, S, Valente, M
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Mendelian Randomization: Concepts and Scope [PDF]

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides a more robust understanding of the influence of these exposures on outcomes because germline ...
Richmond, Rebecca, Davey Smith, George
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Mendelian and Non-Mendelian Quadratic Operators [PDF]

Applied Mathematics & Information Sciences, 2013
In this paper, we attempt to provide mathematical models of Mendelian and Non-Mendelian inheritances of the bisexual population system having Fisher's {\textbf{1:1}} principle. In our model, we always assume that distributions of the same phenotype of female and male populations are equal. We study the evolution of a Mendelian trait.
Ganikhodjaev, Nasir, Saburov, Mansoor, Jamilov, Uygun   +2 more
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Celer: an Efficient Program for Genotype Elimination [PDF]

Electronic Proceedings in Theoretical Computer Science, 2010
This paper presents an efficient program for checking Mendelian consistency in a pedigree. Since pedigrees may contain incomplete and/or erroneous information, geneticists need to pre-process them before performing linkage analysis.
Nicoletta De Francesco, Giuseppe Lettieri, Luca Martini   +2 more
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COVID-19 is associated with the risk of cardiovascular disease death: A two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]

, 2018
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo, Alver, Maris, Bloom, Jonathan M, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Engreitz, Jesse M, Ernst, Jason, Esko, Tonu, Ganna, Andrea, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Khera, Amit V, Lander, Eric S, Manichaikul, Ani, Mitchell, Braxton, Montasser, May, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, O'Connell, Jeffrey R, Peloso, Gina M, Perry, James A, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni E, Salomaa, Veikko, Seed, Cotton, Surakka, Ida L, Vasan, Ramachandran S, Willer, Cristen J, Wilson, James G, Zekavat, Seyedeh Maryam, Zhou, Wei   +36 more
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Evolution of dominance in gene expression pattern associated with phenotypic robustness

BMC Ecology and Evolution, 2021
Background Mendelian inheritance is a fundamental law of genetics. When we consider two genomes in a diploid cell, a heterozygote’s phenotype is dominated by a particular homozygote according to the law of dominance.
Kenji Okubo, Kunihiko Kaneko
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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease [PDF]

, 2017
Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap.
Alexandra Medvedeva, Alison Goate, Ben Saef, Carlos Cruchaga, Joanne Norton, John C. Morris, John P. Budde, Jong Hun Kim, Jorge Del-Aguila, Kathleen Black, Laura Ibañez, Maria Victoria Fernández, null null, null null, Oscar Harari, Rachel Chasse, Umber Dube, Yuetiva Deming   +17 more
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