Results 11 to 20 of about 314,978 (365)

Mendelian Randomization.

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization borrows statistical techniques from economics to allow researchers to analyze the effects of the environment, drug treatments, and other factors on human biology and disease.
E. Birney
semanticscholar   +3 more sources

Mendelian Randomization: Concepts and Scope. [PDF]

Cold Spring Harbor Perspectives in Medicine, 2021
Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides
R. Richmond, G. Davey Smith
semanticscholar   +6 more sources

Mendelian randomization

Nature Reviews Methods Primers, 2022
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
E. Sanderson, M. M. Glymour, M. Holmes, Hyunseung Kang, J. Morrison, M. Munafo, T. Palmer, C. Schooling, Chris Wallace, Qingyuan Zhao, G. Davey Smith   +10 more
semanticscholar   +5 more sources

Mendelian explorations

Journal of Organization Design, 2023
AbstractIn his most recent book, Daniel Levinthal develops a theory of strategy and organization centred around a “Mendelian executive” who consciously seeks new strategic opportunities but is constrained by path dependence to search in spaces adjacent to the current state of affairs.
Marengo, L, Settepanella, S, Valente, M
openaire   +2 more sources

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

British medical journal, 2021
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting.
V. Skrivankova, R. Richmond, B. Woolf, N. Davies, S. Swanson, T. VanderWeele, N. Timpson, J. Higgins, N. Dimou, C. Langenberg, E. Loder, Robert M. Golub, M. Egger, George Davey Smith, J. B. Richards   +14 more
semanticscholar   +1 more source

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

BMC Medicine, 2022
Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization
Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Geng-dong Chen, Dongxin Lin, D. Fan, Xiaoling Guo, Zheng-ping Liu   +8 more
semanticscholar   +1 more source

Episodic neurologic disorders: syndromes, genes, and mechanisms. [PDF]

, 2013
Many neurologic diseases cause discrete episodic impairment in contrast with progressive deterioration. The symptoms of these episodic disorders exhibit striking variety.
Fu, Ying-Hui, Ptáček, Louis J, Russell, Jonathan F   +2 more
core   +2 more sources

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Nature Genetics, 2018
Horizontal pleiotropy occurs when the variant has an effect on disease outside of its effect on the exposure in Mendelian randomization (MR). Violation of the ‘no horizontal pleiotropy’ assumption can cause severe bias in MR.
M. Verbanck, Chia-Yen Chen, B. Neale, R. Do   +3 more
semanticscholar   +1 more source

The role of mutation rate variation and genetic diversity in the architecture of human disease [PDF]

, 2013
Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease.
A Hodgkinson, A Hodgkinson, A Kong, Adam Eyre-Walker, B Charlesworth, B Charlesworth, C Park, CJ Pink, CL Chen, FA Kondrashov, G McVicker, H Ellegren, H Huang, I Hellmann, I Hellmann, I. King Jordan, J Maynard Smith, JA Stamatoyannopoulos, JJ Michaelson, KH Wolfe, L Duret, MJ Lercher, MT Maurano, MW Nachman, NG Smith, R Blekhman, RS Hansen, S Tyekucheva, TI Gossmann, Ying Chen Eyre-Walker   +29 more
core   +4 more sources

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Genetic Epidemiology, 2016
Developments in genome‐wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward.
J. Bowden, G. Davey Smith, P. Haycock, S. Burgess   +3 more
semanticscholar   +1 more source