Results 1 to 10 of about 51,589 (295)
Usefulness of Mendelian Randomization in Observational Epidemiology [PDF]
International Journal of Environmental Research and Public Health, 2010 Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest.
Murielle Bochud, Valentin Rousson
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Introduction to Mendelian randomization. [PDF]
Ann Clin EpidemiolMendelian randomization (MR), i.e. instrumental variable analysis using genetic instruments, is an approach that incorporates population genetics to improve causal inference. Given that genetics are randomly allocated at conception, this resembles the randomization process in randomized controlled trials and hence is more resistant to unobserved ...
Yeung SLA, Luo S, Iwagami M, Goto A.
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Addressing the credibility crisis in Mendelian randomization
BMC MedicineBackground Genome-wide association studies have enabled Mendelian randomization analyses to be performed at an industrial scale. Two-sample summary data Mendelian randomization analyses can be performed using publicly available data by anyone who has ...
Stephen Burgess +4 more
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Nature Reviews Methods Primers, 2022 Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are based on Mendel's laws of inheritance and instrumental variable estimation methods, which enable the inference of causal effects in the presence of ...
Eleanor Sanderson +10 more
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Frontiers in Cardiovascular Medicine, 2022 ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
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Frontiers in Public Health, 2023 BackgroundObservational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding.
Tingting Wang +15 more
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Understanding the Assumptions Underlying Mendelian Randomization [PDF]
European Journal of Human Genetics, 2021 With the rapidly increasing availability of large genetic data sets in recent years, Mendelian Randomization (MR) has quickly gained popularity as a novel secondary analysis method. Leveraging genetic variants as instrumental variables, MR can be used to estimate the causal effects of one phenotype on another even when experimental research is not ...
Christiaan de Leeuw +4 more
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The next step in Mendelian randomization
eLife, 2023 Expanding a statistical approach called Mendelian randomization to include multiple variables may help researchers to identify new molecular causes of specific traits.
Matthias Weith, Andreas Beyer
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Wellcome Open Research, 2020 The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent +5 more
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Pleiotropy-robust Mendelian randomization [PDF]
International Journal of Epidemiology, 2016 AbstractBackgroundThe potential of Mendelian Randomization studies is rapidly expanding due to (i) the growing power of GWAS meta-analyses to detect genetic variants associated with several exposures, and (ii) the increasing availability of these genetic variants in large-scale surveys.
Hans van Kippersluis +4 more
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