Results 1 to 10 of about 60,478 (247)

Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization [PDF]

Brain and Behavior
Background Given inconsistent evidence regarding the migraine‐Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship. Methods GWAS summary statistics for migraine and Alzheimer's disease were
Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu   +9 more
doaj   +2 more sources

COVID-19 is associated with the risk of cardiovascular disease death: A two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
doaj   +1 more source

MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2020
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent, Christopher N. Foley, Andrew J. Grant, Amy M. Mason, James R. Staley, Stephen Burgess   +5 more
doaj   +1 more source

Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study

Frontiers in Public Health, 2023
BackgroundObservational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding.
Tingting Wang, Qi Gao, Yuanyuan Yao, Ge Luo, Tao Lv, Guangxin Xu, Mingxia Liu, Jingpin Xu, Xuejie Li, Dawei Sun, Zhenzhen Cheng, Ying Wang, Chaomin Wu, Ruiyu Wang, Jingcheng Zou, Min Yan   +15 more
doaj   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 1; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj   +1 more source

Causal effects of physical activity on the risk of overall ovarian cancer: A Mendelian randomization study

Digital Health, 2023
Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang, Huanling Zhao, Jiahao Zhu, Minmin Jiang   +3 more
doaj   +1 more source

Statistical methods for Mendelian randomization in genome-wide association studies: A review

Computational and Structural Biotechnology Journal, 2022
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
doaj   +1 more source

Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study

Clinical Epigenetics, 2023
Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan, Xiao Sun, Zhijie Huang, Ruiyuan Zhang, Changwei Li, Amanda H. Anderson, James P. Lash, Tanika N. Kelly   +7 more
doaj   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj   +1 more source

Can we apply the Mendelian randomization methodology without considering epigenetic effects?

Emerging Themes in Epidemiology, 2009
Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried, Zhang Hongmei, Ogbuanu Ikechukwu U   +2 more
doaj   +1 more source