Results 181 to 190 of about 95,337 (328)

E-Values for Mendelian Randomization

Epidemiology, 2020
Swanson, Sonja, VanderWeele, TJ
openaire   +3 more sources

Mendelian randomization: the challenge of unobserved environmental confounds [PDF]

International Journal of Epidemiology, 2019
Koellinger, Philipp D, de Vlaming, Ronald   +1 more
openaire   +3 more sources

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, EarlyView.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Causal relationship between immune cells and idiopathic thrombocytopenic purpura: A bidirectional Mendelian randomization study

Rheumatology &Autoimmunity, EarlyView.
Heyi Zhang, Luyao Song, Ying Mao, Zerui Liu, Zhexi He, Mengxia Liu, Jingfang Zhang, Rui Zhao, Jing Luo, Shengxiao Zhang   +9 more
wiley   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Commentary: Mendelian randomization and women’s health [PDF]

International Journal of Epidemiology, 2019
Censin, JC, Bovijn, J, Holmes, MV, Lindgren, CM   +3 more
openaire   +2 more sources

Biological Aging Acceleration in Major Depressive Disorder: A Multi‐Omics Analysis

Aging Cell, EarlyView.
A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ‐specific levels—including the brain, based on observational and Mendelian Randomization analyses. Our results suggest a complex association between MDD and biological aging acceleration, which can be a novel therapeutic target for this condition ...
Breno Satler Diniz, Shangshu Zhao, Gabin Drouard, Eero Vuoksimaa, Miina Ollikainen, Eric J. Lenze, Ming Xu, Richard H. Fortinsky, George A. Kuchel, Jaakko Kaprio, Chia‐Ling Kuo   +10 more
wiley   +1 more source