Results 11 to 20 of about 51,589 (295)
Mendelian Randomization: Concepts and Scope [PDF]
Cold Spring Harbor Perspectives in Medicine, 2021 Mendelian randomization (MR) is a method of studying the causal effects of modifiable exposures (i.e., potential risk factors) on health, social, and economic outcomes using genetic variants associated with the specific exposures of interest. MR provides a more robust understanding of the influence of these exposures on outcomes because germline ...
George Davey Smith +2 more
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Mendelian randomization in the bone field [PDF]
Bone, 2019 Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement ...
Larsson, Susanna C +2 more
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Digital Health, 2023 Objective Inconsistent results were reported on the association of physical activity with ovarian cancer. However, given the limitations of confounders and inverse causation, the validity of the association remained unclear. Therefore, we conducted a two-
Jing Wang +3 more
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Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
Clinical Epigenetics, 2023 Background Previous studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function phenotypes. However, the temporal and potentially causal relationships between these variables remain unclear.
Yang Pan +7 more
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Mendelian randomization in family data [PDF]
BMC Proceedings, 2009 The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques.
Nathan Morris +3 more
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Nature Communications, 2021 Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new Mendelian Randomization method to estimate bi- directional causal effects and ...
Liza Darrous +2 more
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Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Emerging Themes in Epidemiology, 2009 Introduction Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks.
Karmaus Wilfried +2 more
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Nature Communications, 2022 Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing ...
Lingyan Chen +18 more
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Methodological Challenges in Mendelian Randomization [PDF]
Epidemiology, 2014 We give critical attention to the assumptions underlying Mendelian randomization analysis and their biological plausibility. Several scenarios violating the Mendelian randomization assumptions are described, including settings with inadequate phenotype definition, the setting of time-varying exposures, the presence of gene-environment interaction, the ...
Tyler J. VanderWeele +3 more
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Multivariable Mendelian Randomization and Mediation [PDF]
Cold Spring Harbor Perspectives in Medicine, 2020 Mendelian randomization (MR) is the use of genetic variants associated with an exposure to estimate the causal effect of that exposure on an outcome. Mediation analysis is the method of decomposing the effects of an exposure on an outcome, which act directly, and those that act via mediating variables.
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