Results 191 to 200 of about 4,310,301 (302)
Introduction to Mendelian randomization. [PDF]
Ann Clin EpidemiolYeung SLA, Luo S, Iwagami M, Goto A.
europepmc +1 more source
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization [PDF]
, 2015 Louise A C Millard +5 more
openalex +1 more source
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians
Aging Cell, EarlyView.Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien +11 more
wiley +1 more source
Mendelian Randomization and Colocalization Analysis Reveal New Drug Targets for Oral Ulcer: A Mendelian Randomization Analysis. [PDF]
Health Sci RepZhang X, Fan H, Zhang X, Wang Y, Chen G.
europepmc +1 more source
Aging Cell, EarlyView.A comprehensive causal effect analysis was used to illustrate the associations between gut microbiota, aging indicators, and age‐related diseases. This study provides evidence that supports the association between the gut microbiota and aging and highlights the potential of genetic correlation and causal relationship analysis in biomarker discovery ...
Chunrong Lu +7 more
wiley +1 more source
Erratum to: Introduction to Mendelian randomization. [PDF]
Ann Clin EpidemiolYeung SLA, Luo S, Iwagami M, Goto A.
europepmc +1 more source
Assessing the Genetic Predisposition of Education on Myopia: A Mendelian Randomization Study [PDF]
, 2015 Gabriel Cuéllar-Partida +12 more
openalex +1 more source
Aging Cell, EarlyView.Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou +18 more
wiley +1 more source
Genotype‐driven NPC1L1 and PCSK9 inhibition and reduced risk of periodontitis
Journal of Clinical Periodontology, Volume 50, Issue 1, Page 114-120, January 2023., 2023 Abstract Aim Epidemiological and pre‐clinical studies suggest a chemoprotective role of lipid‐lowering agents in periodontitis. We tested the association of genetically proxied inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGCR), Niemann‐Pick C1‐Like 1 (NPC1L1) and proprotein convertase subtilisin/kexin type 9 (PCSK9) with ...
Sebastian‐Edgar Baumeister +7 more
wiley +1 more source