Results 21 to 30 of about 4,310,301 (302)

Association between serum cystatin C and early impairment of cardiac function and structure in type 2 diabetes patients with normal renal function

Clinical Cardiology, Volume 45, Issue 12, Page 1287-1296, December 2022., 2022
Abstract Background Type 2 diabetes mellitus (T2DM) patients may have cardiac remodeling and dysfunction from the early stage of disease. This study aimed to determine the association between cystatin C (CysC) and early cardiac functional or structural impairment in T2DM patients without renal dysfunction.
Zhuoshan Huang, Junlin Zhong, Shaozhao Zhang, Zhenyu Xiong, Yiquan Huang, Menghui Liu, Yifen Lin, Xiangbin Zhong, Xiaomin Ye, Xiaodong Zhuang, Xinxue Liao   +10 more
wiley   +1 more source

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Genetic Epidemiology, 2016
Developments in genome‐wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward.
J. Bowden, G. Davey Smith, P. Haycock, S. Burgess   +3 more
semanticscholar   +1 more source

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

eLife, 2023
Background: Whether the positive associations of smoking and alcohol consumption with gastrointestinal diseases are causal is uncertain. We conducted this Mendelian randomization (MR) to comprehensively examine associations of smoking and alcohol ...
S. Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang, Xiao-Yang Wang, Xue Li, D. Gill, S. Burgess, E. Giovannucci, S. Larsson   +10 more
semanticscholar   +1 more source

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

Genetic Epidemiology, 2013
Genome‐wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations.
S. Burgess, A. Butterworth, S. Thompson
semanticscholar   +1 more source

Exploring causal correlations between inflammatory cytokines and systemic lupus erythematosus: A Mendelian randomization

Frontiers in Immunology, 2023
Objectives Previous studies have reported that a few inflammatory cytokines have associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and macrophage inflammatory protein (MIP).
Mengmeng Xiang, Yilun Wang, Zhanyan Gao, Jie Wang, Qian Chen, Zhanjuan Sun, Jun Liang, Jinhua Xu   +7 more
semanticscholar   +1 more source

The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

Frontiers in Genetics, 2023
Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang, Duorui Nie, Yujing Chen, Zixing Liu, Mengzhao Li, Chun Gong, Qiong Liu   +6 more
doaj   +1 more source

Interpreting findings from Mendelian randomization using the MR-Egger method

European Journal of Epidemiology, 2017
Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian randomization using summarized genetic data. MR-Egger consists of three parts: (1) a test for directional pleiotropy, (2) a test for a causal effect, and (3) an estimate of the ...
S. Burgess, S. Thompson
semanticscholar   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Ashish Patel, Ting Ye, Haoran Xue, Zhaotong Lin, Siqi Xu, Benjamin Woolf, A. Mason, S. Burgess   +7 more
semanticscholar   +1 more source

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source