Results 21 to 30 of about 51,589 (295)

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

Frontiers in Genetics, 2023
Observational studies have suggested a positive association between gastroesophageal reflux disease and lung cancer, but due to the existence of confounders, it remains undetermined whether gastroesophageal reflux disease (GERD) has a causal association ...
Jing Yang, Duorui Nie, Yujing Chen, Zixing Liu, Mengzhao Li, Chun Gong, Qiong Liu   +6 more
doaj   +1 more source

Graphical analysis for phenome-wide causal discovery in genotyped population-scale biobanks

Nature Communications, 2021
Mendelian randomization is a popular method to detect causal relationships between traits, but can be confounded by instances of horizontal pleiotropy. Here, the authors present a Mendelian randomization workflow which includes causal discovery analysis ...
David Amar, Nasa Sinnott-Armstrong, Euan A. Ashley, Manuel A. Rivas   +3 more
doaj   +1 more source

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza, Stėphane Auvin, Melissa Barker‐Haliski, Anna‐Maria Katsarou, Hana Kubova, Aristea S. Galanopoulou, Bridgette Semple, Christopher A. Reid   +7 more
wiley   +1 more source

Smoking and stroke: A mendelian randomization study [PDF]

Annals of Neurology, 2019
We used the Mendelian randomization design to explore the potential causal association of smoking with ischemic stroke and intracerebral hemorrhage using summary statistics data for 34,217 ischemic stroke cases and 404,630 noncases, and 1,545 cases of intracerebral hemorrhage and 1,481 noncases.
Karl Michaëlsson, Stephen Burgess, Susanna C. Larsson, Susanna C. Larsson   +3 more
openaire   +6 more sources

Causal relationship among obesity and body fat distribution and epilepsy subtypes

Frontiers in Neurology, 2022
ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality.
Kaiping Zhou, Huan Yang, Ruomeng Chen, Weiping Wang, Zhenzhen Qu   +4 more
doaj   +1 more source

Depression and Osteoporosis: A Mendelian Randomization Study [PDF]

Calcified Tissue International, 2021
AbstractObservational studies suggest a link between depression and osteoporosis, but these may be subject to confounding and reverse causality. In this two-sample Mendelian randomization analysis, we included the large meta-analysis of genome-wide association studies for depression among 807,553 individuals (246,363 cases and 561,190 controls) of ...
Zhengxue Quan, Lifeng Yin, Yunsheng Ou, Qiong Lyu, Muzi Zhang, Bin He   +5 more
openaire   +2 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +4 more sources

Guidelines for performing Mendelian randomization investigations [PDF]

Wellcome Open Research, 2019
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts.
Caroline L Relton, Michael V. Holmes, Michael V. Holmes, George Davey Smith, Evropi Theodoratou, Evropi Theodoratou, M. Maria Glymour, Cosetta Minelli, Fernando Pires Hartwig, Fernando Pires Hartwig, Frank Dudbridge, Neil M Davies, Dipender Gill, Stephen Burgess   +13 more
openaire   +2 more sources