Results 31 to 40 of about 4,310,301 (302)
International Journal of Epidemiology, 2003 Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies.
G. Smith, S. Ebrahim
semanticscholar +1 more source
Cancer Medicine, 2023 Metabolic disorders are a hallmark feature of cancer. However, the evidence for the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still lacking.
Zhangjun Yun +6 more
semanticscholar +1 more source
A two-sample Mendelian randomization study of circulating lipids and deep venous thrombosis
Scientific Reports, 2023 In view of the current debate about the relationship between lipids and deep venous thrombosis (DVT) in clinical studies, a two-sample Mendelian randomization (MR) study was conducted to clarify the effects of five circulating lipids (apolipoprotein A1 ...
Pan Luo +4 more
semanticscholar +1 more source
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Human Molecular Genetics, 2014 Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects of modifiable exposures on disease outcomes.
G. Davey Smith, G. Hemani
semanticscholar +1 more source
Nutrients, 2023 Objective: Ankylosing spondylitis (AS) is associated with a variety of gut microbiotas. We aim to analyze the causal relationship between the two at the genetic level.
Ming-juan Yang +7 more
semanticscholar +1 more source
Epilepsia Open, EarlyView., 2022 Abstract Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of experiments using these rodent models, occurring across a diversity of laboratories and commercial vendors, remains an issue impacting the cost‐effectiveness and scientific rigor of the studies performed.
Massimo Mantegazza +7 more
wiley +1 more source
Guidelines for performing Mendelian randomization investigations: update for summer 2023
Wellcome Open Research, 2019 This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization ...
S. Burgess +14 more
semanticscholar +1 more source
Roles of gut microbiome in epilepsy risk: A Mendelian randomization study
Frontiers in Microbiology, 2023 Background Recent studies have suggested an association between gut microbiomes (GMs) and epilepsy. However, the GM taxa identified in different studies are variable. In addition, observational studies cannot indicate causality.
Youjie Zeng, Si Cao, Heng Yang
semanticscholar +1 more source
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
bioRxiv, 2017 Background Mendelian randomisation (MR) is being increasingly used as a strategy to improve causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association ...
F. Hartwig, G. Davey Smith, J. Bowden
semanticscholar +1 more source
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
BMC Medicine, 2023 Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections.
Helene M. Flatby +4 more
semanticscholar +1 more source